An overview of the potential medicinal and pharmaceutical properties of Ru (II)/(III) complexes

A Skoczynska, A Lewinski, M Pokora, P Paneth… - International Journal of …, 2023 - mdpi.com
This review examines the existing knowledge about Ru (II)/(III) ion complexes with a
potential application in medicine or pharmacy, which may offer greater potential in cancer …

Combination of Ru (II) complexes and light: new frontiers in cancer therapy

C Mari, V Pierroz, S Ferrari, G Gasser - Chemical science, 2015 - pubs.rsc.org
The synergistic action of light, oxygen and a photosensitizer (PS) has found applications for
decades in medicine under the name of photodynamic therapy (PDT) for the treatment of …

Construction of homo and heteronuclear Ru (II), Ir (III) and Re (I) complexes for target specific cancer therapy

S Pete, N Roy, B Kar, P Paira - Coordination Chemistry Reviews, 2022 - Elsevier
More than 10 million death tolls in 2020 were reported as a result of heinous impact of
cancer, making it second most prime cause of death after cardiovascular diseases. In …

Detailed account on activation mechanisms of ruthenium coordination complexes and their role as antineoplastic agents

M Pal, U Nandi, D Mukherjee - European Journal of Medicinal Chemistry, 2018 - Elsevier
Ruthenium (Ru) complexes are known for their promising anticancer activity presumably
due to octahedral coordination geometry, slow ligand exchange rate, the range of different …

Biological applications of Ru (II) polypyridyl complexes

M Mital, Z Ziora - Coordination Chemistry Reviews, 2018 - Elsevier
Ru (II) polypyridyl complexes are of great interest for their unique biological, photophysical,
optical, catalytic and electronic properties. This class of complexes demonstrates a number …

Study of ruthenium (II) complexes with anticancer drugs as ligands. Design of metal-based phototherapeutic agents

R Cini, G Tamasi, S Defazio, M Corsini… - Inorganic …, 2003 - ACS Publications
The reaction of trans-[RuCl2 (PPh3) 3](Ph= C6H5) with 2-thio-1, 3-pyrimidine (HTPYM) and
6-thiopurines (TPs) produced mainly crystalline solids that consist of cis, cis, trans-[Ru …

Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes

J Karges, O Blacque, M Jakubaszek, B Goud… - Journal of inorganic …, 2019 - Elsevier
Due to acquired resistance or limitations of the currently approved drugs against cancer,
there is an urgent need for the development of new classes of compounds. Among others …

Design of a tris-heteroleptic Ru (II) complex with red-light excitation and remarkably improved photobiological activity

S Li, J Zhao, X Wang, G Xu, S Gou, Q Zhao - Inorganic Chemistry, 2020 - ACS Publications
Ru (II)-polypyridyl complexes are of increasing interest in photodynamic therapy (PDT) due
to their easily tunable photophysical and photochemical properties. However, short …

Recent advances in ruthenium (II) and iridium (III) complexes containing nanosystems for cancer treatment and bioimaging

J Shen, TW Rees, L Ji, H Chao - Coordination chemistry reviews, 2021 - Elsevier
Ruthenium (II) and iridium (III) coordination compounds display excellent structural,
photophysical, and biological properties which make them highly promising as anticancer …

New ruthenium polypyridyl complexes functionalized with fluorine atom or furan: Synthesis, DNA-binding, cytotoxicity and antitumor mechanism studies

GB Jiang, WY Zhang, M He, YY Gu, L Bai… - … Acta Part A: Molecular …, 2020 - Elsevier
Two novel ruthenium (II) polypyridyl complexes, namely,[Ru (dmp) 2 (CAPIP)](ClO 4) 2 (Ru
(II)-1) and [Ru (dmp) 2 (CFPIP)](ClO 4) 2 (Ru (II)-2), which respectively contain (E)-2-(2 …