A review of the current research on the role of bFGF and VEGF in angiogenesis Page 1
education JOURNAL OF WOUND CARE VOL 18, NO 12, DECEMBER 2009 516 A review of the …

BACKGROUND: A chronic wound is tissue with an impaired ability to heal. This is often a
consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency …

Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The
idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is …

Background. Wound angiogenesis is believed to be initiated by the early rapid release of
preformed growth factors such as basic fibroblast growth factor (bFGF). However, neither the …

Revascularization of damaged tissue is a necessary part of wound healing. With
unregulated or insufficient vessel growth, healing is delayed or pathological. Angiogenesis …

Significance: Angiogenesis, the growth of new blood vessels from existing vessels, is an
important aspect of the repair process. Restoration of blood flow to damaged tissues …

Objectives To test the influence of vascular endothelial growth factor (VEGF) on normal and
ischemic wounds in a noncontractive dermal ulcer standardized model in the rabbit ear and …

Significance: Re-establishment of a functional vascular network is a critical component of
successful wound repair. One of the most potent pro-angiogenic agents is vascular …

Basic fibroblast growth factor (bFGF) was tested for its ability to stimulate angiogenesis in
vivo using the rabbit corneal assay. Basic FGF (50-1,000 ng) was incorporated into 10 …

The influence of subcutaneously injected recombinant human basic fibroblast growth factor
(bFGF) on wound healing in normal (n= 20) and ischaemic (n= 28) skin tissue was …