Purpose To investigate the association of ABCB1-C3435T transition with breast cancer risk
which was followed by a meta-analysis. Methods In a case-control study we collected blood …

BACKGROUND: The second leading cause of cancer-related death in women is breast
cancer. Xenobiotic Metabolizing Enzymes (XMEs) contribute to the detoxification of …

Background Breast cancer is the most common cause of cancer death among women.
Several studies have investigated the relationship between the C3435T polymorphism of …

Breast cancer (BC) is the most common cancer and the second cause of mortality in women
all around the world. It is caused by several factors including genetic determinants, so that …

In first part of this study, a systematic review was designed to explore the involvement of
CYP1A1 and GSTP1 genes in breast cancerogenesis. Based on systematic review, we …

Background: P-glycoprotein (P-gp), a membrane transporter encoded by the multidrug
resistance-1 (MDR1) gene, influences pharmacokinetics and metabolism of anticancer …

We read with great interest a recent article entitled ''Association between two polymorphisms
of ABCB1 and breast cancer risk in the current studies: a meta-analysis''by Lu et al.[1] …

Background Functional variants of the xenobiotic-metabolizing genes (XMG) might modulate
breast cancer (BC) risk by altering the rate of metabolism and clearance of myriad types of …

Gastric cancer is a common cancer worldwide. The multidrug resistance 1 gene (MDR1) is
one of the most important candidate genes for influencing gastric cancer susceptibility. This …

Background: CYP1A1 is a candidate gene for low-penetrance breast cancer susceptibility,
as it plays an important role in the metabolism of carcinogens and estrogens. Purpose: The …