Simple Summary Colorectal cancer (CRC) is among the most common cancers and the third
leading cause of cancer deaths worldwide. Despite the identification of alterations in DNA …

Background Colorectal cancer (CRC) represents a major cause of cancer deaths worldwide.
Although significant progress has been made by molecular and immune therapeutic …

Simple Summary Defective DNA damage response (DDR) is a hallmark of cancer leading to
genomic instability. Up to 15–20% of colorectal cancers carry alterations in DDR. However …

Although several drugs have been designed in the last few years to target specific key
pathways and functions in colorectal cancer (CRC), the backbone of CRC treatment is still …

Purpose: Genomic instability is a hallmark of cancer and targeting DNA damage response
(DDR) is emerging as a promising therapeutic strategy in different solid tumors. The …

Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …

Simple Summary The DNA damage response pathway plays a critical role in maintaining
genomic integrity. Therefore, inhibition of activation of cell-cycle checkpoints involved in this …

DNA damage response, a key factor involved in maintaining genome integrity and stability,
consists of several kinase-dependent signaling pathways, which sense and transduce DNA …

Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA
repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major …