To bypass the biological barriers during the drug delivery process, it is desirable to develop
smart nanoparticles (NPs) with flexible physical and chemical properties. In this study, a …

The efficient delivery of antitumor agents to tumor sites faces numerous obstacles, such as
poor cellular uptake and slow intracellular drug release. In this regard, smart nanoparticles …

Physicochemical properties, including particle size, zeta potential, and drug release
behavior, affect targeting efficiency, cellular uptake, and antitumor effect of nanocarriers in a …

Nanocarriers have been extensively explored for cancer drug delivery with their ability to
respond to cancer heterogeneity which is recently recognized as a critical doorway to a high …

In this work, a pH-sensitive liposome–polymer nanoparticle (NP) composed of lipid,
hyaluronic acid (HA) and poly (β-amino ester)(PBAE) was prepared using layer-by-layer …

To achieve effective intracellular anticancer drug release for boosted antitumor efficacy, the
acidity-responsive nanovehicles for doxorubicin (DOX) delivery were fabricated by tailor …

Tumor microenvironment (TME) targeted strategy could control the drug release in tumor
cells more accurately and creates a new opportunity for enhanced site-specific targeted …

Herein, a smart pH-sensitive nanoparticle (DGL-PEG-Tat-KK-DMA-DOX) was prepared to
achieve the selective intracellular drug delivery. In this nanoparticle, a PEG-grafted cell …

Multi-drug resistance (MDR) of tumor is a major cause of chemotherapy failure. In this study,
a pH-sensitive graft copolymer, poly (β-amino ester)-g-β-cyclodextrin (PBAE-g-β-CD), was …

Efficient approach was established to improve the drug delivery performance of the pH-
triggered prodrug nanoparticles by introducing a polycation block as a pH-sensitive …