A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one
J Christian - Proceedings of the National Academy of …, 2021 - National Acad Sciences
Bone morphogenetic proteins (BMPs) are members of the larger transforming growth factor
β (TGF-β) family of cytokines that play diverse roles in embryonic development, adult tissue …
β (TGF-β) family of cytokines that play diverse roles in embryonic development, adult tissue …
Deciphering the binding code of BMP-receptor interaction
J Nickel, M Dreyer, W Sebald - Bone Morphogenetic Proteins: From …, 2002 - Springer
BMPs and other members of the TGF-13 superfamily are powerful secreted signalling
proteins that determine development and homoeostasis of many organs and tissues [1, 2] …
proteins that determine development and homoeostasis of many organs and tissues [1, 2] …
Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
MJ Solloway, EJ Robertson - Development, 1999 - journals.biologists.com
Members of the BMP family of signaling molecules display a high conservation of structure
and function, and multiple BMPs are often coexpressed in a variety of tissues during …
and function, and multiple BMPs are often coexpressed in a variety of tissues during …
BMP heterodimers signal via distinct type I receptor class functions
Heterodimeric TGF-β ligands outperform homodimers in a variety of developmental, cell
culture, and therapeutic contexts; however, the mechanisms underlying this increased …
culture, and therapeutic contexts; however, the mechanisms underlying this increased …
Molecular recognition in BMP ligand-receptor interactions
S Harth - 2010 - opus.bibliothek.uni-wuerzburg.de
Bone Morphogenetic Proteins (BMPs) are secreted multifunctional signaling proteins that
play an important role during development, maintenance and regeneration of tissues and …
play an important role during development, maintenance and regeneration of tissues and …
BMP signaling requires retromer-dependent recycling of the type I receptor
RJ Gleason, AM Akintobi, BD Grant… - Proceedings of the …, 2014 - National Acad Sciences
The transforming growth factor β (TGFβ) superfamily of signaling pathways, including the
bone morphogenetic protein (BMP) subfamily of ligands and receptors, controls a myriad of …
bone morphogenetic protein (BMP) subfamily of ligands and receptors, controls a myriad of …
Bone morphogenetic protein receptors
H Yamashita, P Ten Dijke, CH Heldin, K Miyazono - Bone, 1996 - Elsevier
Bone morphogenetic proteins (BMPs) were originally identified as proteins that induce bone
formation at extraskeletal sites (reviewed in Reddi33). More recent studies have shown that …
formation at extraskeletal sites (reviewed in Reddi33). More recent studies have shown that …
[HTML][HTML] The beauty of seeing the real thing: BMP heterodimer detection in vivo reveals dimer composition and activity
GM Collu, M Mlodzik - Developmental Cell, 2023 - Elsevier
BMP family ligands can direct cells to divide, differentiate, or die, depending on cell context
and specific hetero-or homodimer combinations. In this issue of Developmental Cell, Bauer …
and specific hetero-or homodimer combinations. In this issue of Developmental Cell, Bauer …
[PDF][PDF] BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II
T Kirsch, J Nickel, W Sebald - The EMBO journal, 2000 - embopress.org
Bone morphogenetic protein-2 (BMP-2) induces bone formation and regeneration in adult
vertebrates and regulates important developmental processes in all animals. BMP-2 is a …
vertebrates and regulates important developmental processes in all animals. BMP-2 is a …
The crystal structure of the BMP-2: BMPR-IA complex and the generation of BMP-2 antagonists
J Nickel, MK Dreyer, T Kirsch, W Sebald - JBJS, 2001 - journals.lww.com
Background: Bone morphogenetic proteins (BMPs) and growth and differentiation factors
(GDFs) belong to the large transforming growth factor-β (TGF-β) superfamily of …
(GDFs) belong to the large transforming growth factor-β (TGF-β) superfamily of …