Previous studies have indicated that males are at a higher risk of developing hepatocellular
carcinoma (HCC) compared with females. Identifying the factors that cause this gender …

Hepatocellular carcinoma (HCC) is one of the male-dominant liver diseases with poor
prognosis, although treatments for HCC have been progressing in the past decades …

Background: Hepatocellular carcinoma (HCC) is a solid cancer with high predominance in
males. Liver tissue of both genders has saturable specific oestrogen receptors. Androgen …

Hepatocellular carcinoma (HCC) represents a major health problem worldwide with steadily
increasing incidence rates, particularly in developed Western countries. Currently, HCC is …

The most common form of primary liver malignancy is hepatocellular carcinoma (HCC).
HCC, evolving in the setting of chronic liver disease (CLD) and cirrhosis, accounted globally …

BACKGROUND: Androgen receptors (ARs) act as transcription factors. An increased AR
activity could be due either to mutations or to an increased expression of the receptor. AR …

The androgen receptor (AR) plays an important role in male-dominant hepatocellular
carcinoma, and specific acquired somatic mutations of AR have been observed in HCC …

Androgen/androgen receptor (AR) signaling plays important roles in normal liver function
and in progression of liver diseases. In studies of non-cancerous liver diseases, AR …

Early reports suggested androgen/androgen receptor (AR) signals promote
hepatocarcinogenesis. However, all antiandrogen clinical trials failed in advanced …

Owing to the marked sexual dimorphism of hepatocellular carcinoma (HCC), sex hormone
receptor signaling has been implicated in numerous aspects of liver cancer pathogenesis …