Limb girdle muscular dystrophy type 2D (LGMD2D) is characterized by progressive
weakening of muscles in the hip and shoulder girdles. It is caused by a mutation in the α …

Limb girdle muscular dystrophies (LGMD) are a very heterogenous group of diseases
causing progressive muscle wasting in the hip and shoulder girdles. LGMD2D is caused by …

The activin receptor type IIB (ActRIIB) is a transmembrane receptor for transforming growth
factor-β superfamily members, including myostatin, that are involved in the negative …

Inhibition of signalling via the activin receptor IIB (ActRIIB) is considered a promising
therapeutic strategy for Duchenne muscular dystrophy (DMD). A soluble form of activin …

Background Inhibition of activin/myostatin pathway has emerged as a novel approach to
increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a …

Duchenne muscular dystrophy (DMD) is a recessive disease caused by a dystrophin gene
mutation. Myoblast transplantation permits the introduction of the dystrophin gene into …

Inhibition of the myostatin signaling pathway is emerging as a promising therapeutic means
to treat muscle wasting and degenerative disorders. Activin type IIB receptor (ActRIIB) is the …

Modulation of transforming growth factor‐β (TGF‐β) signaling to promote muscle growth
holds tremendous promise for the muscular dystrophies and other disorders involving the …

Postnatal blockade of the activin type IIB receptor (ActRIIB) represents a promising
therapeutic strategy for counteracting dystrophic muscle wasting. However, its impact on …

Spinal muscular atrophy (SMA) is a devastating neurodegenerative disorder that causes
progressive muscle atrophy and weakness. Using adeno-associated virus-mediated gene …