Mechanisms of therapeutic antitumor monoclonal antibodies

LC Tsao, J Force, ZC Hartman - Cancer research, 2021 - AACR
Monoclonal antibodies (mAb) are a major component of cancer therapy. In this review, we
summarize the different therapeutic mAbs that have been successfully developed against …

[HTML][HTML] Monoclonal antibodies in cancer therapy

D Zahavi, L Weiner - Antibodies, 2020 - mdpi.com
Monoclonal antibody-based immunotherapy is now considered to be a main component of
cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies …

Trial Watch: Monoclonal antibodies in cancer therapy

L Galluzzi, E Vacchelli, WH Fridman, J Galon… - …, 2012 - Taylor & Francis
Since the advent of hybridoma technology, dating back to 1975, monoclonal antibodies
have become an irreplaceable diagnostic and therapeutic tool for a wide array of human …

Trial Watch: Tumor-targeting monoclonal antibodies in cancer therapy

E Vacchelli, F Aranda, A Eggermont, J Galon… - …, 2014 - Taylor & Francis
In 1997, for the first time in history, a monoclonal antibody (mAb), ie, the chimeric anti-CD20
molecule rituximab, was approved by the US Food and Drug Administration for use in …

Trial watch: Monoclonal antibodies in cancer therapy

E Vacchelli, A Eggermont, J Galon… - …, 2013 - Taylor & Francis
During the past 20 years, dozens—if not hundreds—of monoclonal antibodies have been
developed and characterized for their capacity to mediate antineoplastic effects, either as …

Monoclonal antibodies: versatile platforms for cancer immunotherapy

LM Weiner, R Surana, S Wang - Nature Reviews Immunology, 2010 - nature.com
Antibodies are important therapeutic agents for cancer. Recently, it has become clear that
antibodies possess several clinically relevant mechanisms of action. Many clinically useful …

Monoclonal antibodies for the treatment of cancer

CW Shuptrine, R Surana, LM Weiner - Seminars in cancer biology, 2012 - Elsevier
Over the past decade, the clinical utility of monoclonal antibodies has been realized and
antibodies are now a mainstay for the treatment of cancer. Antibodies have the unique …

Building better monoclonal antibody-based therapeutics

GJ Weiner - Nature Reviews Cancer, 2015 - nature.com
For 20 years, monoclonal antibodies (mAbs) have been a standard component of cancer
therapy, but there is still much room for improvement. Efforts continue to build better cancer …

Antibody therapy of cancer

AM Scott, JD Wolchok, LJ Old - Nature reviews cancer, 2012 - nature.com
The use of monoclonal antibodies (mAbs) for cancer therapy has achieved considerable
success in recent years. Antibody–drug conjugates are powerful new treatment options for …

Fc receptor-dependent mechanisms of monoclonal antibody therapy of cancer

JE Bakema, M van Egmond - Fc Receptors, 2014 - Springer
Targeted therapies like treatment with monoclonal antibodies (mAbs) have entered the
arsenal of modern anticancer drugs. mAbs combine specificity with multiple effector …