Revisit the Inhibitory Effects of Glucocorticoids on Immunocytes

S Wu, S Zhao, Y Zhong, B Wang - bioRxiv, 2023 - biorxiv.org
Glucocorticoids (GCs) are efficacious agents for reducing inflammation and suppressing
immune responses, exerting various effects on immune cells through the intracellular …

New insights into the cell-and tissue-specificity of glucocorticoid actions

L Quatrini, S Ugolini - Cellular & molecular immunology, 2021 - nature.com
Glucocorticoids (GCs) are endogenous hormones that are crucial for the homeostasis of the
organism and adaptation to the external environment. Because of their anti-inflammatory …

After 62 years of regulating immunity, dexamethasone meets COVID-19

DW Cain, JA Cidlowski - Nature Reviews Immunology, 2020 - nature.com
Six months into the COVID-19 pandemic, effective treatments have been frustratingly sparse.
The RECOVERY clinical trial, however, revealed that treatment with dexamethasone, a …

Application of glucocorticoids in patients with novel coronavirus infection: From bench to bedside

L Lu, J Huang, X Deng, X Sun, J Dong - Traditional Medicine and …, 2020 - World Scientific
Glucocorticoids (GCs) have potential anti-inflammatory and immunosuppressive effects.
There is plenty of controversy about the application of glucocorticoids in the treatment of …

[HTML][HTML] More than suppression: glucocorticoid action on monocytes and macrophages

JM Ehrchen, J Roth, K Barczyk-Kahlert - Frontiers in immunology, 2019 - frontiersin.org
Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …

[PDF][PDF] INHIBITORY EFFECTS OF GLUCOCORTICOID ON IMMUNOCYTES

S Wu, S Zhao, Y Zhong, B Wang - researchgate.net
Effective anti-inflammatory and immunosuppressive drugs, glucocorticoids (GCs) influence
both innate and adaptive immunity via the intracellular glucocorticoid receptor (GR) …

Glucocorticoids and COVID-19

S Bruscoli, PG Puzzovio, M Zaimi, K Tiligada… - Pharmacological …, 2022 - Elsevier
Abstract Coronavirus Disease 19 (COVID-19) is associated with high morbidity and mortality
rates globally, representing the greatest health and economic challenge today. Several …

[HTML][HTML] The Role of Glucocorticoids in the Management of COVID-19

VI Alexaki, H Henneicke - Hormone and Metabolic Research, 2021 - thieme-connect.com
Coronavirus disease 2019 (COVID-19), caused by an infection with the novel coronavirus
SARS-CoV-2, has resulted in a global pandemic and poses an emergency to public health …

Dexamethasone for severe COVID-19: how does it work at cellular and molecular levels?

T Kino, I Burd, JH Segars - International journal of molecular sciences, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) caused by infection of the severe respiratory
syndrome coronavirus-2 (SARS-CoV-2) significantly impacted human society. Recently, the …

[HTML][HTML] Tailoring glucocorticoids in patients with severe COVID-19: a narrative review

MH Luo, YQ Qian, DL Huang, JC Luo, Y Su… - Annals of …, 2021 - ncbi.nlm.nih.gov
Objective To discuss the pathogenesis of severe coronavirus disease 2019 (COVID-19)
infection and the pharmacological effects of glucocorticoids (GCs) toward this infection. To …