Distinct effects of dexamethasone on human natural killer cell responses dependent on cytokines
DJ Morgan, DM Davis - Frontiers in immunology, 2017 - frontiersin.org
Glucocorticoids (GCs) have long been known to be immune suppressive and synthetic
variants are widely used in the treatment of inflammatory disorders. Here, we report that …
variants are widely used in the treatment of inflammatory disorders. Here, we report that …
Dexamethasone counteracts the immunostimulatory effects of triiodothyronine (T3) on dendritic cells
MM Montesinos, VA Alamino, ID Mascanfroni… - Steroids, 2012 - Elsevier
Glucocorticoids (GCs) are widely used as anti-inflammatory and immunosuppressive
agents. Several studies have indicated the important role of dendritic cells (DCs), highly …
agents. Several studies have indicated the important role of dendritic cells (DCs), highly …
Glucocorticoids severely impair differentiation and antigen presenting function of dendritic cells despite upregulation of Toll-like receptors
Glucocorticoids (GCs) are widely used as anti-inflammatory and immunosuppressive
agents. Effects of GC have mainly been attributed to the suppression of T cells. Recently …
agents. Effects of GC have mainly been attributed to the suppression of T cells. Recently …
Abstract 1756 Molecular Mechanism of Macrophage Plasticity Mediated by Dexamethasone and Aldosterone
B Neiderlander, M Kadmiel - Journal of Biological Chemistry, 2024 - ASBMB
Synthetic glucocorticoids (GCs) and mineralocorticoids (MCs) have been utilized within the
medical field for over 70 years for their broad versatility in modulating the immune response …
medical field for over 70 years for their broad versatility in modulating the immune response …
Glucocorticoids: inflammation and immunity
MG Petrillo, CD Bortner, JA Cidlowski - … pituitary-adrenal axis in health and …, 2017 - Springer
Glucocorticoids are universally prescribed as the drug of choice for the treatment of
inflammatory and autoimmune disorders. These stress hormones act through their cognate …
inflammatory and autoimmune disorders. These stress hormones act through their cognate …
Effectiveness of corticosteroids to treat severe COVID-19: a systematic review and meta-analysis of prospective studies
H Li, B Yan, R Gao, J Ren, J Yang - International Immunopharmacology, 2021 - Elsevier
Objectives To assess the effects of corticosteroid therapy for patients with severe
coronavirus disease 2019 (COVID-19). Methods We comprehensively searched articles …
coronavirus disease 2019 (COVID-19). Methods We comprehensively searched articles …
Real-world evidence of the use of glucocorticoids for severe COVID-19
A Albarrán-Sánchez… - Therapeutic …, 2022 - journals.sagepub.com
Introduction: Currently, only glucocorticoids have proved to impact adverse outcomes in
COVID-19. However, their risk/benefit balance remains inconclusive and populations' …
COVID-19. However, their risk/benefit balance remains inconclusive and populations' …
The effect of glucocorticoids on mortality in severe COVID-19 patients: Evidence from 13 studies involving 6612 cases
GQ Yu, ZH Jiang, ZB Yang, SQ Jiang, XQ Quan - Medicine, 2021 - journals.lww.com
Background: Since the start of the coronavirus disease 2019 (COVID-19) pandemic, there is
an urgent need for effective therapies for patients with COVID-19. In this study, we aimed to …
an urgent need for effective therapies for patients with COVID-19. In this study, we aimed to …
Adverse outcomes associated with corticosteroid use in critical COVID-19: a retrospective multicenter cohort study
Corticosteroid is commonly used to reduce damage from inflammatory reactions in
coronavirus disease 2019 (COVID-19). We aim to determine the outcomes of corticosteroid …
coronavirus disease 2019 (COVID-19). We aim to determine the outcomes of corticosteroid …
Glucocorticoid compounds in drug discovery by targeting glucocorticoid receptor protein
W Yi, M Wu, F Chen, Z Zhou - Privileged Scaffolds in Drug Discovery, 2023 - Elsevier
Glucocorticoids targeting the glucocorticoid receptor (GR) as the most potent and effective
agents for treating inflammation disease are widely used on the drug market. However, even …
agents for treating inflammation disease are widely used on the drug market. However, even …