Background Alcohol use disorder (AUD) and schizophrenia (SCZ) frequently co-occur, and
large-scale genome-wide association studies (GWAS) have identified significant genetic …

Background and aim Schizophrenia (SCZ) and bipolar disorder (BD) have a high
comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol …

Background: While genetic influences on alcohol dependence (AD) are substantial,
progress in the identification of individual genetic variants that impact on risk has been …

Genome-wide association studies (GWAS) of complex traits, such as alcohol use disorders
(AUD), usually identify variants in non-coding regions and cannot by themselves distinguish …

Almost half of individuals diagnosed with schizophrenia also present with a substance use
disorder, however, little is known about potential molecular mechanisms underlying this …

Alcohol use disorders (AUDs) are complex psychiatric disorders that can be viewed as the
progression of a series of transitions (eg, initiation of use, escalation to hazardous drinking …

Background There are high levels of comorbidity between schizophrenia and substance use
disorder, but little is known about the genetic etiology of this comorbidity. Methods We tested …

Individuals with schizophrenia frequently experience co-occurring substance use, including
tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in …

BackgroundSubstance use occurs at a high rate in persons with a psychiatric disorder.
Genetically informative studies have the potential to elucidate the etiology of these …

Background A recent study investigated the genetic associations and latent genetic structure
among eight psychiatric disorders using findings from genome-wide association studies …