[HTML][HTML] Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations
The complex aetiology of schizophrenia is postulated to share components with other
psychiatric disorders. We investigated pleiotropy amongst the common variant genomics of …
psychiatric disorders. We investigated pleiotropy amongst the common variant genomics of …
The relationship between case–control differential gene expression from brain tissue and genetic associations in schizophrenia
NE Clifton, A Schulmann… - American Journal of …, 2023 - Wiley Online Library
Large numbers of genetic loci have been identified that are known to contain common risk
alleles for schizophrenia, but linking associated alleles to specific risk genes remains …
alleles for schizophrenia, but linking associated alleles to specific risk genes remains …
Item-level genome-wide association study of the alcohol use disorders identification test in three population-based cohorts
Objective: Genome-wide association studies (GWASs) of the Alcohol Use Disorders
Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated …
Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated …
Genome-wide association analysis of Parkinson's disease and schizophrenia reveals shared genetic architecture and identifies novel risk loci
Background Parkinson's disease (PD) and schizophrenia (SCZ) are heritable brain
disorders that involve dysregulation of the dopaminergic system. Epidemiological studies …
disorders that involve dysregulation of the dopaminergic system. Epidemiological studies …
[PDF][PDF] Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants
Genome-wide association studies (GWASs) have successfully identified 145 genomic
regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging …
regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging …
Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets
D Curtis - Psychiatric Genetics, 2018 - journals.lww.com
Background The polygenic risk score (PRS) is derived from single nucleotide
polymorphisms (SNPs) including those that are genome-wide significant and also including …
polymorphisms (SNPs) including those that are genome-wide significant and also including …
A review of genome-wide association studies of stimulant and opioid use disorders
KP Jensen - Complex Psychiatry, 2016 - karger.com
Substance use disorders (SUD) are a major contributor to disability and disease burden
worldwide. Risk for developing SUDs is influenced by variation in the genome. Identifying …
worldwide. Risk for developing SUDs is influenced by variation in the genome. Identifying …
Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects
Common genetic variants identified in genome-wide association studies (GWAS) show
varying degrees of genetic pleiotropy across complex human disorders. Clinical studies of …
varying degrees of genetic pleiotropy across complex human disorders. Clinical studies of …
[HTML][HTML] Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice
JL Doherty, MJ Owen - Genome medicine, 2014 - Springer
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
[HTML][HTML] Disentangling heterogeneity in substance use disorder: Insights from genome-wide polygenic scores
L Vilar-Ribó, J Cabana-Domínguez, S Alemany… - Translational …, 2024 - nature.com
Substance use disorder (SUD) is a global health problem with a significant impact on
individuals and society. The presentation of SUD is diverse, involving various substances …
individuals and society. The presentation of SUD is diverse, involving various substances …