Aging leads to a decline in immune cell function, which leaves the organism vulnerable to
infections and age-related multimorbidities. One major player of the adaptive immune …

Cellular life depends mostly on the creation, modification, interactions and destruction of
proteins. This is true for every cell, including human T lymphocytes. One way these cells can …

In this review, we discuss in detail the most relevant proteolytic systems that together with
chaperones contribute to creating the proteostasis network that is kept in dynamic balance to …

The proteasome degradation machinery is essential for a variety of cellular processes
including senescence and T‐cell immunity. Decreased proteasome activity is associated …

Aging, in the immune system, is characterized by a decreased ability to respond to
exogenous insults, resulting in increased susceptibility to infections and blunted response to …

Deterioration of the immune system with aging (" immunosenescence") is believed to
contribute to morbidity and mortality in man due to the greater incidence of infection, as well …

Deterioration of the immune system with aging (" immunosenescence") is believed to
contribute to morbidity and mortality in man due to the greater incidence of infection, as well …

Aging is a biological and multifactorial process characterized by a progressive and
irreversible deterioration of the physiological functions leading to a progressive increase in …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

[Frontiers in Bioscience 6, d248-261, February 1, 2001] 248 T CELL SENESCENCE Phyllis-Jean
Linton and Marilyn L. Thoman Sidney Page 1 [Frontiers in Bioscience 6, d248-261, February 1 …