Over the past 40 to 50 years, we have made strides in understanding the molecular
underpinnings of oxidative stress and its consequences in severe traumatic brain injury …

Objective To investigate the relationship between oxygenation and short-term outcomes in
patients with traumatic brain injury (TBI). Design Logistic regression analysis was used to …

Cerebral oxygenation represents the balance between oxygen delivery, consumption and
utilization by the brain, and therefore reflects the adequacy of cerebral perfusion. Different …

Pre-hospital resuscitation of critically injured patients traditionally includes supplemental
oxygen therapy to address potential hypoxemia. The objective of this study was to explore …

Oxygen is crucial for aerobic cellular metabolism; however, mitochondrial respiration can
also form reactive oxygen species (ROS)[1], the level of which directly correlates with …

Objective: In this study, available medical literature were reviewed to determine whether
brain hypoxia as measured by brain tissue oxygen (Bto 2) levels is associated with …

Background Early hyperoxia may be an independent risk factor for mortality in critically ill
traumatic brain injury (TBI) patients, although current data are inconclusive. Accordingly, we …

The excellent work by Rezoagli [1] on behalf of the CENTER-TBI and OxENTER-TBI
consortia contributes further evidence of the potentially harmful effects of hyperoxia after …

Objective: The role of hyperoxia in patients with traumatic brain injury (TBI) remains
controversial. The objective of this study was to determine the association between …

Background Supplemental oxygen administration to critically ill patients is ubiquitous in the
intensive care unit (ICU). Uncertainty persists as to whether hyperoxia is benign in patients …