Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro

V Tanos, A Brzezinski, O Drize, N Strauss… - European Journal of …, 2002 - Elsevier
Objective: Genistein is a phytoestrogen with in vitro anticancerogenic activity. We examined
in vitro the effects of genistein alone, or in combination with estradiol and tamoxifen, on the …

Estrogenic Effects of Genistein on the Growth of Estrogen Receptor-positive Human Breast Cancer (MCF-7) Cells in Vitro and in Vivo

CY Hsieh, RC Santell, SZ Haslam, WG Helferich - Cancer research, 1998 - AACR
Genistein, found in soy products, is a phytochemical with several biological activities. In the
current study, our research focused on the estrogenic and proliferation-inducing activity of …

Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro

L Fioravanti, V Cappelletti, P Miodini, E Ronchi… - Cancer letters, 1998 - Elsevier
Genistein significantly inhibited cell growth (IC50 around 10 μM) of MCF-7, MDAMB-231 and
HBL-100 cell lines, but not of skin-derived fibroblasts and counteracted the growth …

Genistein enhances insulin-like growth factor signaling pathway in human breast cancer (MCF-7) cells

WF Chen, MS Wong - The Journal of Clinical Endocrinology & …, 2004 - academic.oup.com
Physiological concentration of genistein, a natural isoflavonoid phytoestrogen, stimulates
human breast cancer (MCF-7) cells proliferation. In this study, we hypothesize that low …

Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21waf/cip1, p27kip1, and …

RS Frey, J Li, KW Singletary - Biochemical pharmacology, 2001 - Elsevier
Genistein, a soy isoflavone, has been reported to inhibit the multiplication of numerous
neoplastic cells, including those in the breast. However, there is limited information on the …

Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice

M Du, X Yang, JA Hartman, PS Cooke… - …, 2012 - academic.oup.com
The present study examined the effect of dietary genistein, a soy isoflavone, on breast
cancer patients who take tamoxifen, an antiestrogen treatment, using a preclinical model …

Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells

MC Pagliacci, M Smacchia, G Migliorati… - European Journal of …, 1994 - Elsevier
Genistein, a natural isoflavonoid phyto-oestrogen, inhibits the tyrosine kinase activity of
growth factor receptors and oncogene products, as well as the in vitro growth of some …

Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro

DT Zava, G Duwe - 1997 - Taylor & Francis
Experimental and epidemiologic studies support the view that soyfoods prevent cancer as
well as diseases and symptoms associated with estrogen deficiency. Recent research …

[HTML][HTML] Inhibitory actions of genistein in human breast cancer (MCF-7) cells

WF Chen, MH Huang, CH Tzang, M Yang… - Biochimica et Biophysica …, 2003 - Elsevier
Genistein, a natural isoflavanoid phytoestrogen, is thought to be the active ingredient in soy
that possesses breast cancer preventive properties. The molecular mechanisms that are …

Effective chemopreventive activity of genistein against human breast cancer cells

YH Shon, SD Park, KS Nam - BMB Reports, 2006 - koreascience.kr
Chemopreventive and cytotoxic effect of genistein against human breast cancer cell lines
was investigated. Genistein inhibited cell proliferation in estrogen receptor-positive (MCF-7) …