Effect of ABCB1 (3435C> T) and CYP3A5 (6986A> G) genes polymorphism on tacrolimus concentrations and dosage requirements in liver transplant patients
M Helal, M Obada, W Abd Elrazek, M Safan… - Egyptian Journal of …, 2017 - ajol.info
Background: Tacrolimus (TAC) is an immunosuppressant used in organ transplant
recipients. It is a substrate of drug transporter ABCB1 as well as of cytochrome P4503A …
recipients. It is a substrate of drug transporter ABCB1 as well as of cytochrome P4503A …
[PDF][PDF] The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients
A Provenzani, M Notarbartolo, M Labbozzetta… - Ann transplant, 2009 - academia.edu
Background: Tacrolimus is a substrate of cytochrome P-450 (CYP) 3A enzyme and of the
drug transporter ABCB1. We have investigated the effects of possible relevant CYP3A5 and …
drug transporter ABCB1. We have investigated the effects of possible relevant CYP3A5 and …
Tacrolimus dose requirement in relation to donor and recipient ABCB1 and CYP3A5 gene polymorphisms in Chinese liver transplant patients
W Wei‐lin, J Jing, Z Shu‐sen, W Li‐hua… - Liver …, 2006 - Wiley Online Library
The aim of this study was to investigate whether the heterogeneity in tacrolimus dose
requirement is associated with ABCB1 and CYP3A5 gene polymorphisms in Chinese liver …
requirement is associated with ABCB1 and CYP3A5 gene polymorphisms in Chinese liver …
[PDF][PDF] Association between tacrolimus concentration and genetic polymorphisms of CYP3A5 and ABCB1 during the early stage after liver transplant in an Iranian …
M Rahsaz, N Azarpira, S Nikeghbalian… - Exp Clin …, 2012 - academia.edu
Objectives: Tacrolimus is widely used as an immunosuppressive drug in liver transplant
recipients with a narrow therapeutic range and variable individualized pharmacokinetics …
recipients with a narrow therapeutic range and variable individualized pharmacokinetics …
Recipient ABCB1, donor and recipient CYP3A5 genotypes influence tacrolimus pharmacokinetics in liver transplant cases
SM Naushad, A Pavani, Y Rupasree, T Hussain… - Pharmacological …, 2019 - Springer
Background Effective immunosuppression through optimization of trough levels tacrolimus
reduces post-transplant mortality rate in liver transplant cases. Methods Meta-analysis was …
reduces post-transplant mortality rate in liver transplant cases. Methods Meta-analysis was …
Influence of CYP3A5 and ABCB1 gene polymorphisms and other factors on tacrolimus dosing in Caucasian liver and kidney transplant patients
A Provenzani, M Notarbartolo… - International …, 2011 - spandidos-publications.com
Tacrolimus is a substrate of cytochrome P4503A (CYP3A) enzymes as well as of the drug
transporter ABCB1. We have investigated the possible influence of CYP3A5 and ABCB1 …
transporter ABCB1. We have investigated the possible influence of CYP3A5 and ABCB1 …
1199G> A and 2677G> T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation
L Elens, A Capron, V Van Kerckhove… - Pharmacogenetics …, 2007 - journals.lww.com
Objective Tacrolimus is an immunosuppressive drug widely used in hepatic transplantation
to avoid graft rejection. Its pharmacokinetics is characterized by a large interindividual …
to avoid graft rejection. Its pharmacokinetics is characterized by a large interindividual …
The effect of ABCB1 C3435T polymorphism on pharmacokinetics of tacrolimus in liver transplantation: a meta-analysis
YY Liu, C Li, Z Cui, X Fu, S Zhang, LL Fan, J Ma, G Li - Gene, 2013 - Elsevier
Objectives The effect of ABCB1 C3435T SNP on the pharmacokinetics of
immunosuppressive drug tacrolimus in different studies was conflicting. So a meta-analysis …
immunosuppressive drug tacrolimus in different studies was conflicting. So a meta-analysis …
[HTML][HTML] Influences of donor and recipient gene polymorphisms on tacrolimus dosing and pharmacokinetics in Asian liver transplant patients
ML Yee, HH Tan, WJ Sia, WP Yau - Open Journal of Organ Transplant …, 2013 - scirp.org
Background: Tacrolimus pharmacokinetics has large inter-individual variability. Objectives:
This study aimed to investigate the impact of donor and recipient gene polymorphisms on …
This study aimed to investigate the impact of donor and recipient gene polymorphisms on …
[PDF][PDF] Combinational effect of CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics in liver transplant patients
JA Buendía, E Otamendi, MC Kravetz, F Cairo… - Exp Clin …, 2015 - researchgate.net
Objectives: Previous studies have reported reduced tacrolimus dose-adjusted exposure in
individuals expressing the CYP3A5* 1 allele (reference singlenucleotide polymorphism …
individuals expressing the CYP3A5* 1 allele (reference singlenucleotide polymorphism …