Free l-glutamate-induced modulation in oxidative and neurochemical profile contributes to enhancement in locomotor and memory performance in male rats

S Tabassum, S Ahmad, S Madiha, S Shahzad… - Scientific reports, 2020 - nature.com
Glutamate (Glu), the key excitatory neurotransmitter in the central nervous system, is
considered essential for brain functioning and has a vital role in learning and memory …

Single microinjection of L‐glutamate induces oxidative stress in discrete regions of rat brain

GN Babu, M Bawari - IUBMB Life, 1997 - Wiley Online Library
Glutamate (Glu) is a major excitatory aminoacid neurotransmitter in the mammalian brain.
Under Certain Circumstances Glu can also exert toxic effects on neuronal Cells. To unravel …

Is L-Glutamate toxic to neurons and thereby contributes to neuronal loss and neurodegeneration? A systematic review

MN Al-Nasser, IR Mellor, WG Carter - Brain sciences, 2022 - mdpi.com
L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory
neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu …

Ameliorative effect of lithium chloride against d-galactose induced behavioral and memory impairment, oxidative stress and alteration in serotonin function in rats

N Samad, I Imran, I Zulfiqar, K Bilal - Pharmacological Reports, 2019 - Elsevier
Background Aging is a phenomenon that all living organisms surely face. d-galactose (D-
gal) has been used to develop an aging model of brain. Lithium (Li) has been proposed to …

[HTML][HTML] Effect of monosodium glutamate on behavioral phenotypes, biomarkers of oxidative stress in brain tissues and liver enzymes in mice

S Umukoro, GO Oluwole, HE Olamijowon… - World Journal of …, 2015 - scirp.org
The effects of oral administration of low doses of monosodium glutamate (MSG) on
behavioral phenotypes, biomarkers of oxidative stress in the brain and liver enzymes in mice …

Evidence of alterations in brain structure and antioxidant status following 'low-dose'monosodium glutamate ingestion

OJ Onaolapo, AY Onaolapo, MA Akanmu, O Gbola - Pathophysiology, 2016 - Elsevier
Objective The study investigated the effects of low dose monosodium glutamate (MSG) on
the brain, with a view to providing information on its effects on neuronal morphology and …

Assessment of neuroprotective effects of Gallic acid against glutamate-induced neurotoxicity in primary rat cortex neuronal culture

S Maya, T Prakash, K Madhu - Neurochemistry international, 2018 - Elsevier
Glutamate excitotoxicity plays a crucial role in the pathogenesis behind the development
and progression of several neurodegenerative diseases. The study aimed to investigate the …

Attenuated glutamate induced ROS production by antioxidative compounds in neural cell lines

H Xin, Y Cui, Z An, Q Yang, X Zou, N Yu - RSC advances, 2019 - pubs.rsc.org
Glutamate is an excitatory neurotransmitter involved in neural function. Excess accumulation
of intercellular glutamate leads to increasing concentration of reactive oxygen species …

Impact of oral supplementation of Glutamate and GABA on memory performance and neurochemical profile in hippocampus of rats.

S Tabassum, S Ahmad, S Madiha… - Pakistan journal of …, 2017 - search.ebscohost.com
Glutamate (GLU) and gamma-amino butyric acid (GABA) are essential amino acids (AA) for
brain function serving as excitatory and inhibitory neurotransmitter respectively. Their tablets …

Effects of L-2-hydroxyglutaric acid on various parameters of the glutamatergic system in cerebral cortex of rats

D Junqueira, AM Brusque, LO Porciúncula… - Metabolic brain …, 2003 - Springer
Abstract L-2-Hydroxyglutaric acid (LGA) accumulates and is the biochemical hallmark of the
neurometabolic disorder L-2-hydroxyglutaric aciduria (LHGA). Although this disease is …