Life expectancy of humans has increased continuously up to the present days, but their
health status (healthspan) was not enhanced by similar extent. To decrease enormous …

Ketone bodies have potential disease-modifying activity that represent a novel therapeutic
approach for neurodegenerative diseases (NDD). The aim of this systematic review was to …

We randomly assigned 23 older adults with mild cognitive impairment to either a high
carbohydrate or very low carbohydrate diet. Following the 6-week intervention period, we …

Background Brain amyloid deposition and neurofibrillary tangles in Alzheimer's disease
(AD) are associated with complex neuroinflammatory reactions such as microglial activation …

Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …

The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As a diet
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …

At present, the prevalence of Alzheimer's disease, a devastating neurodegenerative
disorder, is increasing. Although the mechanism of the underlying pathology is not fully …

Ketone bodies (KBs), such as acetoacetate and β-hydroxybutyrate, serve as crucial
alternative energy sources during glucose deficiency. KBs, generated through ketogenesis …

Ketogenic diets and orally administered exogenous ketone supplements are strategies to
increase serum ketone bodies serving as an alternative energy fuel for high energy …

Optimal cognitive functions are necessary for activities of daily living and self-independence.
Cognitive abilities are acquired during early childhood as part of progressive …