In addition to obesity, many factors, including the distribution of body fat, contribute to the
development of insulin resistance and type 2 diabetes mellitus (T2DM). Lipid contained …

Background Fatty infiltration of the skeletal muscle is a common but poorly understood
feature of many myopathies. It is best described in human muscle, where non-invasive …

Earlier we have shown a significant positive association between muscle fiber distribution, ie
percentage of slow-twitch (ST) fibers in the vastus lateralis muscle, and serum high-density …

Regional differences in the content of intramyocellular lipids (IMCL), extramyocellular lipids,
and total creatine (TCr) were quantified in soleus (S), tibialis posterior (TP), and tibialis …

Intramyocellular lipid (IMCL) content has been reported to decrease after prolonged
submaximal exercise in active muscle and, therefore, seems to form an important local …

Key points Muscle glycogen and intramuscular triglycerides (IMTG, stored in lipid droplets)
are important energy substrates during prolonged exercise. Exercise‐induced changes in …

Lipids are the most abundant organic constituents in many humans. The rise in obesity
prevalence has prompted a need for a more refined understanding of the effects of lipid …

Prolonged high-fat diets (HFDs) can cause intramyocellular lipid (IMCL) accumulation that
may negatively affect muscle function. We investigated the duration of a HFD required to …

We examined whether, in human obesity and type 2 diabetes, long chain fatty acid (LCFA)
transport into skeletal muscle is upregulated and contributes to an excess intramuscular …

Skeletal muscle is the major site for insulin-stimulated glucose disposal, and muscle insulin
resistance confers many negative health outcomes. Muscle is composed of multiple fiber …