Aims/hypothesis Intramyocellular lipids (IMCL) accumulation is a classical feature of
metabolic diseases. We hypothesised that IMCL accumulate mainly as a consequence of …

Muscle lipid increases with high-fat feeding and diabetes. In trained athletes, increased
muscle lipid is not associated with insulin resistance, a phenomenon known as the athlete's …

Fatty acids derived from adipose tissue lipolysis, intramyocellular triacylglycerol lipolysis, or
de novo lipogenesis serve a variety of functions in skeletal muscle. The two major fates of …

The investigation of intramyocellular lipids (IMCLs) with proton MR spectroscopy (1H‐MRS)
in humans has recently received increasing attention. IMCL levels correlate with insulin …

Intramyocellular triacylglycerol (IMTG) is emerging as an important energy fuel source
during muscle contraction and are adaptively increased in response to exercise, without …

Myosteatosis is the pathologic accumulation of lipid that can occur in conjunction with
atrophy and fibrosis following skeletal muscle injury. Little is known about the mechanisms …

Although it is clear that lipids are responsible for insulin resistance, it is poorly understood
what types of lipids are involved. In this study, we verified the characteristic lipid species in …

Background Ageing is accompanied by sarcopenia and intramuscular fat (IMAT) infiltration.
In skeletal muscle, fat infiltration is a common feature in several myopathies and is …

Insulin resistance is closely related to intramyocellular lipid (IMCL) accumulation, and both
are associated with increasing age. It remains to be determined to what extent perturbations …

Altered skeletal muscle lipid metabolism is a hallmark feature of type 2 diabetes (T2D). We
investigated muscle lipid turnover in T2D versus BMI-matched control subjects (controls) …