Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance‐trained males in a fasted state

LJC Van Loon, R Koopman… - The Journal of …, 2003 - Wiley Online Library
Both stable isotope methodology and fluorescence microscopy were applied to define the
use of intramuscular triglyceride (IMTG) stores as a substrate source during exercise on a …

Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2

DA Miranda, TR Koves, DA Gross, A Chadt… - Journal of Biological …, 2011 - ASBMB
Triacylglyceride stored in cytosolic lipid droplets (LDs) constitutes a major energy reservoir
in most eukaryotes. The regulated turnover of triacylglyceride in LDs provides fatty acids for …

Excess accumulation of lipid impairs insulin sensitivity in skeletal muscle

SS Park, YK Seo - International Journal of Molecular Sciences, 2020 - mdpi.com
Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a
living organism. Compelling evidence supports a role for excess fatty acids synthesized in …

Effects of weight loss and physical activity on muscle lipid content and droplet size

J He, BH Goodpaster, DE Kelley - Obesity research, 2004 - Wiley Online Library
Objectives: To address the potential effects of weight loss and physical activity (WL+ Ex) on
intramyocellular lipid (IMCL) and lipid droplet size in overweight and obese previously …

Intramuscular lipid utilization during exercise: a systematic review, meta-analysis, and meta-regression

JR Stokie, G Abbott, KF Howlett… - Journal of Applied …, 2023 - journals.physiology.org
Intramuscular lipid (IMCL) utilization during exercise was controversial as numerous studies
did not observe a decline in IMCL content post-exercise when assessed in muscle biopsies …

Subcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscle

REK MacPherson, EAF Herbst… - American Journal …, 2012 - journals.physiology.org
Skeletal muscle lipid droplet-associated proteins (PLINs) are thought to regulate lipolysis
through protein-protein interactions on the lipid droplet surface. In adipocytes, PLIN2 …

Content of intramyocellular lipids derived by electron microscopy, biochemical assays, and 1H-MR spectroscopy

H Howald, C Boesch, R Kreis… - Journal of Applied …, 2002 - journals.physiology.org
Three different methods to determine intramyocellular lipid (IMCL) contents in human
skeletal muscle have been compared. 1H-magnetic resonance spectroscopy (MRS) was …

Mouse model of skeletal muscle adiposity: a glycerol treatment approach

DF Pisani, CDK Bottema, C Butori, C Dani… - Biochemical and …, 2010 - Elsevier
Fat cell accumulation in skeletal muscle is a major characteristic of various disorders, such
as obesity, sarcopenia and dystrophies. Moreover, these fat cells could be involved in …

Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride …

SS Bakke, C Moro, N Nikolić, NP Hessvik… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Development of insulin resistance is positively associated with dietary saturated fatty acids
and negatively associated with monounsaturated fatty acids. To clarify aspects of this …

Lipid-induced insulin resistance in skeletal muscle: the chase for the culprit goes from total intramuscular fat to lipid intermediates, and finally to species of lipid …

SM Kitessa, MY Abeywardena - Nutrients, 2016 - mdpi.com
The skeletal muscle is the largest organ in the body. It plays a particularly pivotal role in
glucose homeostasis, as it can account for up to 40% of the body and for up to 80%–90% of …