The prognosis of metastatic melanoma has not changed throughout the 20th century.
However, in the last decade, we have witnessed a continuous improvement in survival, with …

Introduction In the last few years, the advent of targeted therapy and immunotherapy has
improved the management and the prognosis of metastatic melanoma, but the spread of …

The survival of advanced metastatic melanoma has been greatly improved within the past
few years. New therapeutic strategies like kinase inhibitors for BRAF-mutant melanoma and …

The first case of malignant melanoma in the United States was reported by a young
physician, Isaac Parish, at Wills Hospital in Philadelphia. On January 7, 1837, he assumed …

Patients with bulky metastatic melanoma still represent a major problem for clinicians.
Despite all therapeutic advances complete remissions of metastatic lesions are rare and the …

Recently treatment strategies in advanced malignant melanoma have significantly changed.
Due to high response rates (eg more than 50% for the Dartmouth-regimen), combination …

The early part of this century has demonstrated major breakthroughs in the treatment of
metastatic melanoma. The introduction of new systemic therapies, including targeted and …

Malignant melanoma, a tumor arising from the transformation of melanocytes, has been
increasing in incidence worldwide for the past three decades. Melanoma that has …

Importance In recent years, the management of metastatic melanoma has been transformed
by the emergence of immune checkpoint inhibitors and targeted therapies that significantly …

Immune checkpoint inhibitors and MAP kinase pathway-targeted therapies have
revolutionized the management of advanced melanoma, and significantly prolong the …