In metastatic melanoma, although immunotherapy extends progression-free survival (PFS)
and provides long-term control of micrometastatic diseases, the response rate remains …

Malignant melanoma, a tumor arising from the transformation of melanocytes, has been
increasing in incidence worldwide for the past three decades. Melanoma that has …

Immune checkpoint inhibitors and MAP kinase pathway-targeted therapies have
revolutionized the management of advanced melanoma, and significantly prolong the …

The early part of this century has demonstrated major breakthroughs in the treatment of
metastatic melanoma. The introduction of new systemic therapies, including targeted and …

Importance In recent years, the management of metastatic melanoma has been transformed
by the emergence of immune checkpoint inhibitors and targeted therapies that significantly …

Immune checkpoint inhibition and targeted therapies have revolutionized the treatment of
melanoma. However, chemotherapy and interleukin 2 (IL-2) therapy may still have a role in …

Improved understanding of melanoma genetics and immune regulatory pathways have
culminated in the development of targeted and immunotherapies of the patients with …

Malignant melanoma is a tumor that originates from the melanocytes and manifests mainly
on the skin. Melanomas are usually strongly pigmented, however amelanoticformshavebeen …

Abstract Purpose of Review For patients with metastatic melanoma, immune checkpoint
inhibition has drastically changed outcomes. Here, we review the current and next …

Abstract Purpose of Review In this article, we will briefly review the current treatment
landscape for metastatic melanoma and provide a comprehensive update on emerging …