The pharmacological disruption of the interaction between the HIV Tat protein and its
cognate transactivation response RNA (TAR) would generate novel anti-viral drugs with a …

The interaction of the HIV-1 transactivator protein Tat with its transactivation response (TAR)
RNA is an essential step in viral replication and therefore an attractive target for developing …

The interaction between the HIV-1 Tat protein and the TAR RNA element in the nascent viral
genomic transcript is required for viral replication. An 11-residue β-peptide (1), an all-β …

The human immunodeficiency virus type-1 (HIV-1) Tat protein stimulates transcriptional
elongation. Tat is introduced to the transcription machinery by binding to the transactivation …

One of the first steps in HIV gene expression is the recruitment of Tat protein to the
transcription machinery after its binding to the RNA response element TAR. Starting from a …

Revised Manuscript Received May 8, 1995® abstract: Basic peptides from the carboxy
terminus of the human immunodeficiency virus type 1 (HIV-1) Tat protein bind to the stem …

An oligoribonucleotide, corresponding to the Tat-interactive top half of the HIV-1 TAR RNA
stem-loop, was synthesized in both the natural d-and the enantiomeric l-configurations. The …

Efficient transcription from the human immunodeficiency virus (HIV) promoter depends on
binding of the viral regulatory protein Tat to a cis-acting RNA regulatory element, TAR. Tat …

The binding site for tat protein on TAR RNA has been defined in quantitative terms using an
extensive series of mutations. The relative dissociation constants for the mutant TAR RNAs …

The Human Immunodeficiency Virus type 1 Tat protein interacts specifically with a U-rich
bulge within an RNA stem− loop known as the trans-activation responsive region (TAR) that …