RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms …

microRNAs (miRNAs) are non-coding RNAs that regulate gene expression post-
transcriptionally, and mounting evidence supports the prevalence and functional …

Muscle-specific transcription factor MyoD orchestrates the myogenic gene expression
program by binding to short DNA motifs called E-boxes within myogenic cis-regulatory …

The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …

The RNA-binding protein (RBP) HuR is one of the most widely studied regulators of the
eukaryotic posttranscriptional gene expression and it plays a physiological role in mediating …

Long noncoding (lnc) RNAs potently regulate gene expression programs in physiology and
disease. Here, we describe a key function for lncRNA OIP5-AS1 in myogenesis, the process …

Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–
rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3 …

HuR, a protein that binds to specific mRNA subsets, is increasingly recognized as a pivotal
posttranscriptional regulator of gene expression. Here, HuR was immunoprecipitated under …

ColQ is a specific collagen that anchors acetylcholinesterase (AChE) in the synaptic cleft of
the neuromuscular junction (NMJ). The importance of AChE-ColQ complex in the physiology …

During myogenic differentiation, acetylcholinesterase (AChE) transcriptlevels are known to
increase dramatically. Although this increase can beattributed in part to increased …