[HTML][HTML] Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression

HEC Sharp, HD Critchley, JA Eccles - World journal of psychiatry, 2021 - ncbi.nlm.nih.gov
The mind is embodied; thoughts and feelings interact with states of physiological arousal
and physical integrity of the body. In this context, there is mounting evidence for an …

[HTML][HTML] Joint hypermobility links neurodivergence to dysautonomia and pain

JLL Csecs, V Iodice, CL Rae, A Brooke… - Frontiers in …, 2022 - frontiersin.org
Objectives Autism, attention deficit hyperactivity disorder (ADHD), and tic disorder (Tourette
syndrome; TS) are neurodevelopmental conditions that frequently co-occur and impact …

Variant connective tissue (joint hypermobility) and dysautonomia are associated with multimorbidity at the intersection between physical and psychological health

JLL Csecs, NG Dowell, GK Savage… - American Journal of …, 2021 - Wiley Online Library
The symptoms of joint hypermobility extend beyond articular pain. Hypermobile people
commonly experience autonomic symptoms (dysautonomia), and anxiety or related …

Emotion processing in joint hypermobility: a potential link to the neural bases of anxiety and related somatic symptoms in collagen anomalies

N Mallorquí-Bagué, A Bulbena, N Roé-Vellvé… - European …, 2015 - cambridge.org
Background: Joint hypermobility syndrome (JHS) has repeatedly been associated with
anxiety and anxiety disorders, fibromyalgia, irritable bowel syndrome and …

Joint hypermobility and autonomic hyperactivity: relevance to neurodevelopmental disorders

JA Eccles, V Iodice, NG Dowell, A Owens… - Journal of Neurology …, 2014 - jnnp.bmj.com
Objective To test the hypothesis that Joint hypermobility and autonomic dysfunction are over-
expressed within neurodevelopmental disorders. Joint hypermobility is a widespread poorly …

[HTML][HTML] Neurodevelopmental, neuropsychiatric and psychosocial correlates of joint hypermobility and related disorders

V Guinchat, C Baeza-Velasco, A Bulbena… - Frontiers in …, 2022 - frontiersin.org
This Research Topic is concerned with the intriguing overlap between apparently separated
aspects of human variability: congenital contortionism (aka generalized joint hypermobility; …

Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms

JA Eccles, FDC Beacher, MA Gray… - The British Journal of …, 2012 - cambridge.org
Joint hypermobility is overrepresented among people with anxiety and can be associated
with abnormal autonomic reactivity. We tested for associations between regional cerebral …

[HTML][HTML] Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint …

N Mallorquí-Bagué, SN Garfinkel, M Engels… - Frontiers in …, 2014 - frontiersin.org
Objective: Anxiety is associated with increased physiological reactivity and also increased
“interoceptive” sensitivity to such changes in internal bodily arousal. Joint hypermobility, an …

Joint hypermobility, anxiety and psychosomatics: two and a half decades of progress toward a new phenotype

A Bulbena, G Pailhez, A Bulbena-Cabré… - Clinical challenges in …, 2015 - karger.com
The strong association between a heritable collagen condition and anxiety was an
unexpected finding that we first described in 1988 at the Hospital del Mar in Barcelona …

[HTML][HTML] Joint hypermobility and autonomic hyperactivity: an autonomic and functional neuroimaging study

J Eccles, A Owens, N Harrison, R Grahame, H Critchley - The Lancet, 2016 - thelancet.com
Background Joint hypermobility is a common connective tissue variant. Surprisingly, people
with this disorder are especially vulnerable to anxiety. Recent imaging studies suggest that …