Ginsenoside 20 (S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats

N Jiang, L Jingwei, H Wang, H Huang, Q Wang… - Behavioural Brain …, 2020 - Elsevier
Abstract 20 (S)-protopanaxadiol (PPD) possesses a variety of biological activities, including
antioxidant, antifatigue and anti-inflammatory properties. This study was aimed to investigate …

Ginsenoside‐Rg1 rescues stress‐induced depression‐like behaviors via suppression of oxidative stress and neural inflammation in rats

Y Li, L Wang, P Wang, C Fan, P Zhang… - Oxidative medicine …, 2020 - Wiley Online Library
Depression is an inflammatory‐related condition, with the progression in neuronal damage
resulting in major depression disorder. Ginsenoside‐Rg1, a sterol extract from the herb …

The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats

Z Liu, Y Qi, Z Cheng, X Zhu, C Fan, SY Yu - Neuroscience, 2016 - Elsevier
Depression is a common neuropsychiatric disorder which has been associated with a wide
range of structural and functional changes within specific brain regions. Ginsenoside Rg1 …

Neuroprotective effects of ginsenoside-Rg1 against depression-like behaviors via suppressing glial activation, synaptic deficits, and neuronal apoptosis in rats

C Fan, Q Song, P Wang, Y Li, M Yang… - Frontiers in …, 2018 - frontiersin.org
Depression is considered a neuropsychiatric disease associated with various neuronal
changes within specific brain regions. We previously reported that ginsenoside-Rg1, a …

[HTML][HTML] Ginsenoside Rg1 prevents chronic stress-induced depression-like behaviors and neuronal structural plasticity in rats

H Yu, C Fan, L Yang, S Yu, Q Song, P Wang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Ginsenoside Rg1 has been demonstrated to exhibit neuroprotective
effects in various studies. This study aimed to investigate the neuronal mechanisms …

Ginsenoside Rg1 reverses stress‐induced depression‐like behaviours and brain‐derived neurotrophic factor expression within the prefrontal cortex

X Zhu, R Gao, Z Liu, Z Cheng, Y Qi… - European Journal of …, 2016 - Wiley Online Library
Depression is a major neuropsychiatric disorder that exerts deleterious effects upon public
health. However, the neuronal mechanisms of depression remain largely uncharacterized …

Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation

N Jiang, J Lv, H Wang, H Huang, Q Wang, C Lu… - Life sciences, 2020 - Elsevier
Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal
model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major …

[HTML][HTML] Ginsenoside Rg3 exerts anti-depressive effect on an NMDA-treated cell model and a chronic mild stress animal model

H Zhang, Z Zhou, Z Chen, Z Zhong, Z Li - Journal of Pharmacological …, 2017 - Elsevier
Depression is a common mental disorder and a leading cause of disability. At its most
severe, it can lead to suicide. Recently, there has been growing interest in the application of …

Ginsenosides Rb1 Attenuates Chronic Social Defeat Stress-Induced Depressive Behavior via Regulation of SIRT1-NLRP3/Nrf2 Pathways

N Jiang, Y Zhang, C Yao, H Huang, Q Wang… - Frontiers in …, 2022 - frontiersin.org
Ginsenoside Rb1, a diol-type ginseng saponin, has various positive effects on the central
nervous system. This study aimed to evaluate the antidepressant effects of Rb1 on chronic …

Antidepressant‐like effects of 20(S)‐protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms

N Jiang, J Lv, H Wang, Q Wang, C Lu… - Phytotherapy …, 2019 - Wiley Online Library
20 (S)‐Protopanaxadiol (PPD) is a basic aglycone of the dammarane triterpenoid saponins
and exerts antidepressant‐like effects on behaviour in the forced swimming test (FST) and …