The genetic model system Drosophila has contributed fundamentally to our understanding
of mammalian heart specification, development, and congenital heart disease. The relatively …

The Drosophila heart, also called the dorsal vessel, is an organ for hemolymph circulation
that resembles the vertebrate heart at its transient linear tube stage. Dorsal vessel …

The Drosophila cardiac tube was once thought to be a simple linear structure, however
research over the past 15 years has revealed significant cellular and molecular complexity …

Heart development is an evolutionarily conserved process. The cardiac organ of Drosophila
melanogaster is the dorsal vessel, a linear contractile tissue with cellular and morphogenetic …

Heart formation relies on two sources of cardiomyocytes: the first heart field (FHF), which
gives rise to the linear heart tube, and the second heart field (SHF), which gives rise to the …

The Drosophila heart, also referred to as the dorsal vessel, pumps the insect blood, the
hemolymph. The bilateral heart primordia develop from the most dorsally located …

Specification of cardiac primordia and formation of the Drosophila heart tube is highly
reminiscent of the early steps of vertebrate heart development. We previously reported that …

Signal transduction through multiple distinct pathways regulates and orchestrates the
numerous biological processes comprising heart development. This review outlines the …

The Drosophila heart tube seems simple, yet it has notable anatomic complexity and
contains highly specialized structures. In fact, the development of the fly heart tube much …

The heart is the first organ to form and function during vertebrate development and is
absolutely essential for life. The left ventricle is derived from the classical primary or first …