The dysregulated immune system represents a major target for improving health outcomes
in a range of chronic conditions. This chapter describes key changes in the immune system …

Historically, autoimmune-inflammatory disorders were subdivided into autoinflammatory vs.
autoimmune diseases. About a decade ago, an immunological continuum was proposed …

Studying the human immune system is challenging. These challenges stem from the
complexity of the immune system itself, the heterogeneity of the immune system between …

The principle of precision medicine is most established in oncology; eg choice of particular
treatment based on the presence of certain molecular alterations within the tumors (1). This …

The interplay between the immune system and the metabolic state of a cell is intricate. In all
phases of an immune response, the corresponding metabolic changes shall occur to …

An interesting paradox in healthcare is that while health literacy increased in the last
decade, expected improvements in health prospects are lagging. Due to global trends such …

From the standpoint of an Adult Rheumatologist, we have a lot to learn from our Pediatric
Rheumatology colleagues. A start to this process is presented in an extraordinarily unique …

Immunotherapy: Making the case for precision medicine | Science Translational Medicine
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As our understanding of immune-mediated chronic inflammatory diseases (IMIDs) grows, it
becomes more and more clear that these conditions result from the convergence of a …

Personalized medicine encompasses a broad and evolving field informed by a patient
distinctive information and biomarker profile. Although terminology is evolving and some …