Dysregulated iron homeostasis plays a central role in the development of anemia of chronic
kidney disease (CKD) and is a major contributor toward resistance to treatment with …

Iron is an essential element for numerous fundamental biologic processes, but excess iron is
toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney …

Iron is essential for most living organisms but iron excess can be toxic. Cellular and systemic
iron balance is therefore tightly controlled. Iron homeostasis is dysregulated in chronic …

Anemia is a complication that affects a majority of individuals with advanced CKD. Although
relative deficiency of erythropoietin production is the major driver of anemia in CKD, iron …

Controversies in iron management. Background Iron therapy is required in hemodialysis
patients receiving erythropoietic stimulators in order to achieve the target hemoglobin in the …

Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

Iron-deficiency frequently develops in patients with chronic kidney disease who are treated
with recombinant human erythropoietin (rHuEPO). It results in reduced effectiveness of …

New insights into iron regulation and erythropoiesis : Current Opinion in Hematology New
insights into iron regulation and erythropoiesis : Current Opinion in Hematology Log in or …

Background: Regulation of body iron occurs at cellular, tissue, and systemic levels. In
healthy individuals, iron absorption and losses are minimal, creating a virtually closed …

Iron deficiency is prevalent in patients with chronic kidney disease (CKD), and use of oral
and intravenous iron in patients with CKD who do not require dialysis might obviate or delay …