Development and characterization of novel dendritic cell (DC)-targeting vaccine against human immunodeficiency virus (HIV)-1 envelope conserved elements (CEs)

M Mahmoudi - 2021 - mspace.lib.umanitoba.ca
Abstract Development of the human immunodeficiency virus type-1 (HIV-1) vaccine is an
effective and powerful prevention method of the halting pandemic of the acquired …

Development and evaluation of an Ebola virus glycoprotein mucin-like domain replacement system as a new dendritic cell-targeting vaccine approach against HIV-1

Z Ao, L Wang, H Azizi, TA Olukitibi, G Kobinger… - Journal of …, 2021 - Am Soc Microbiol
The development of efficient vaccine approaches against HIV infection remains challenging
in the vaccine field. Here, we developed an Ebola virus envelope glycoprotein (EboGP) …

[HTML][HTML] Incorporation of Ebola glycoprotein into HIV particles facilitates dendritic cell and macrophage targeting and enhances HIV-specific immune responses

Z Ao, L Wang, EJ Mendoza, K Cheng, W Zhu… - PloS one, 2019 - journals.plos.org
The development of an effective vaccine against HIV infection remains a global priority.
Dendritic cell (DC)-based HIV immunotherapeutic vaccine is a promising approach which …

[HTML][HTML] Dendritic cells/macrophages-targeting feature of Ebola glycoprotein and its potential as immunological facilitator for antiviral vaccine approach

TA Olukitibi, Z Ao, M Mahmoudi, GA Kobinger, X Yao - Microorganisms, 2019 - mdpi.com
In the prevention of epidemic and pandemic viral infection, the use of the antiviral vaccine
has been the most successful biotechnological and biomedical approach. In recent times …

Immunogenicity testing of a novel engineered HIV-1 envelope gp140 DNA vaccine construct

S Kumar, J Yan, K Muthumani… - DNA and cell …, 2006 - liebertpub.com
DNA vaccines expressing the envelope (env) of the human immunodeficiency virus type 1
(HIV-1) have been relatively ineffective at generating strong immune responses. In this …

Immunogenicity of virus-like particles containing modified human immunodeficiency virus envelope proteins

FS Quan, G Sailaja, I Skountzou, C Huang, A Vzorov… - Vaccine, 2007 - Elsevier
Extensive glycosylation and variable loops of the HIV envelope protein (Env) are reported to
shield some neutralizing epitopes. Here, we investigated the immunogenicity of mutated HIV …

Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine

J Yan, N Corbitt, P Pankhong, T Shin, A Khan… - Vaccine, 2011 - Elsevier
DNA vaccines require significant engineering in order to generate strong CTL responses in
both non-human primates and humans. In this study, we designed a clade C env gene …

[HTML][HTML] Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines

L Ye, Z Wen, K Dong, X Wang, Z Bu, H Zhang… - PloS one, 2011 - journals.plos.org
Several conserved neutralizing epitopes have been identified in the HIV Env protein and
among these, the MPER of gp41 has received great attention and is widely recognized as a …

Construction and evaluation of DNA vaccine encoding Ebola virus glycoprotein fused with lysosome-associated membrane protein

Y Liu, B Sun, J Pan, Y Feng, W Ye, J Xu, M Lan, H Sun… - Antiviral Research, 2021 - Elsevier
Ebola virus (EBOV) of the genus Ebolavirus belongs to the family Filoviridae, which cause
disease in both humans and non-human primates. Zaire Ebola virus accounts for the highest …

A novel mechanism of immune evasion mediated by Ebola virus soluble glycoprotein

CF Basler - Expert review of anti-infective therapy, 2013 - Taylor & Francis
Evaluation of: Mohan GS, Li W, Ye L, Compans RW, Yang C. Antigenic subversion: a novel
mechanism of host immune evasion by Ebola virus. PLoS Pathog. 8 (12), e1003065 (2012) …