The role of (shared) genetics and environment in (co-occurring) psychiatric problems, substance use, and obesity
R Wang - 2023 - research.rug.nl
Psychiatric disorders, substance use, and obesity often co-occur. These problems not only
co-occur within the same person but also co-aggregate within families. However, the …
co-occur within the same person but also co-aggregate within families. However, the …
Familial co-aggregation and shared heritability between depression, anxiety, obesity and substance use
Depression, anxiety, obesity and substance use are heritable and often co-occur. However,
the mechanisms underlying this co-occurrence are not fully understood. We estimated their …
the mechanisms underlying this co-occurrence are not fully understood. We estimated their …
The actions and interactions of family genetic risk scores for alcohol use disorder and major depression on the risk for these two disorders
KS Kendler, SL Lönn, J Sundquist… - American Journal of …, 2022 - Wiley Online Library
We know little about how genetic risk factors for two disorders jointly act and interact in
predisposing to illness. Therefore, in the Swedish population, born 1970–1990 (n …
predisposing to illness. Therefore, in the Swedish population, born 1970–1990 (n …
Polygenic prediction of the phenome, across ancestry, in emerging adulthood
BackgroundIdentifying genetic relationships between complex traits in emerging adulthood
can provide useful etiological insights into risk for psychopathology. College-age individuals …
can provide useful etiological insights into risk for psychopathology. College-age individuals …
Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits
Epidemiological studies show high comorbidity between different mental health problems,
indicating that individuals with a diagnosis of one disorder are more likely to develop other …
indicating that individuals with a diagnosis of one disorder are more likely to develop other …
Shared genetic risk between eating disorder‐and substance‐use‐related phenotypes: Evidence from genome‐wide association studies
Eating disorders and substance use disorders frequently co‐occur. Twin studies reveal
shared genetic variance between liabilities to eating disorders and substance use, with the …
shared genetic variance between liabilities to eating disorders and substance use, with the …
Major depressive disorder and lifestyle: correlated genetic effects in extended twin pedigrees
In recent years, evidence has accumulated with regard to the ubiquity of pleiotropy across
the genome, and shared genetic etiology is thought to play a large role in the widespread …
the genome, and shared genetic etiology is thought to play a large role in the widespread …
A polygenic score for body mass index is associated with depressive symptoms via early life stress: Evidence for gene-environment correlation
Increasing childhood obesity rates are associated with not only adverse physical, but also
mental health outcomes, including depression. These negative outcomes may be caused …
mental health outcomes, including depression. These negative outcomes may be caused …
Using patterns of genetic association to elucidate shared genetic etiologies across psychiatric disorders
Twin studies indicate that latent genetic factors overlap across comorbid psychiatric
disorders. In this study, we used a novel approach to elucidate shared genetic factors across …
disorders. In this study, we used a novel approach to elucidate shared genetic factors across …
SEPARATING DIRECT AND ENVIRONMENTALLY MEDIATED GENETIC CONTRIBUTIONS TO PSYCHIATRIC RISK USING FAMILY-LEVEL GENOMIC DATA
A Allegrini, A Havdahl, JB Pingault - European Neuropsychopharmacology, 2023 - Elsevier
Transmission of psychiatric risk across generations is a complex phenomenon. We can
distinguish two broad types of intergenerational effects. On the one hand,“direct” or …
distinguish two broad types of intergenerational effects. On the one hand,“direct” or …