T cells are required for an effective adaptive immune response. The principal function of T
cells is to promote efficient removal of foreign material by identifying and mounting a specific …

It is now clear that access to specific metabolic programmes controls the survival and
function of various immune cell populations, including T cells. Efficient naïve and memory T …

T cell survival, differentiation after stimulation, and function are intrinsically linked to distinct
cellular metabolic states. The ability of T cells to readily transition between metabolic states …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

The progressive decline of the anatomical architecture and loss of functional integrity of an
individual is aging. Accumulation of degenerative cellular and molecular changes in the …

Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …

T cell-mediated immune responses are compromised in aged individuals, leading to
increased morbidity and reduced response to vaccination. While cellular metabolism tightly …

Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

Aging represents an emerging challenge for public health due to the declined immune
responses against pathogens, weakened vaccination efficacy, and disturbed tissue …

Metabolic reprogramming is a hallmark of T cell activation and function. As our
understanding of T cell metabolism increases, so does our appreciation of its inherent …