Toward improving androgen receptor-targeted therapies in male-dominant hepatocellular carcinoma
Highlights•AR is an oncogenic driver of hepatocellular carcinoma.•AR-targeted therapy is
limited by feedback activation of AKT-mTOR pathway.•Co-targeting of mTORC1 and AR may …
limited by feedback activation of AKT-mTOR pathway.•Co-targeting of mTORC1 and AR may …
[PDF][PDF] Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross‐talk in hepatocellular …
H Zhang, XX Li, Y Yang, Y Zhang, HY Wang… - …, 2018 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a male‐dominant cancer, and androgen receptor (AR)
has been linked to the pathogenesis of HCC. However, AR expression and its precise role in …
has been linked to the pathogenesis of HCC. However, AR expression and its precise role in …
Transcriptionally active androgen receptor splice variants promote hepatocellular carcinoma progression
Owing to the marked sexual dimorphism of hepatocellular carcinoma (HCC), sex hormone
receptor signaling has been implicated in numerous aspects of liver cancer pathogenesis …
receptor signaling has been implicated in numerous aspects of liver cancer pathogenesis …
[HTML][HTML] Hepatocellular carcinoma: Latest research in pathogenesis, detection and treatment
The most common form of primary liver malignancy is hepatocellular carcinoma (HCC).
HCC, evolving in the setting of chronic liver disease (CLD) and cirrhosis, accounted globally …
HCC, evolving in the setting of chronic liver disease (CLD) and cirrhosis, accounted globally …
[HTML][HTML] Androgen receptor could be a potential therapeutic target in patients with advanced hepatocellular carcinoma
T Kanda, K Takahashi, M Nakamura, S Nakamoto… - Cancers, 2017 - mdpi.com
Hepatocellular carcinoma (HCC) is a male-dominant disease with poor prognosis. Sorafenib
is the only approved systemic chemotherapeutic drug for patients with advanced HCC …
is the only approved systemic chemotherapeutic drug for patients with advanced HCC …
[HTML][HTML] Constitutively active androgen receptor in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the predominant type of liver cancer and a leading
cause of cancer-related death globally. It is also a sexually dimorphic disease with a male …
cause of cancer-related death globally. It is also a sexually dimorphic disease with a male …
[PDF][PDF] Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis
Early reports suggested androgen/androgen receptor (AR) signals promote
hepatocarcinogenesis. However, all antiandrogen clinical trials failed in advanced …
hepatocarcinogenesis. However, all antiandrogen clinical trials failed in advanced …
[HTML][HTML] Androgen receptor in hepatocarcinogenesis: Recent developments and perspectives
YE Tian, XU Xie, Y Lin, G Tan… - Oncology …, 2015 - spandidos-publications.com
Previous studies have indicated that males are at a higher risk of developing hepatocellular
carcinoma (HCC) compared with females. Identifying the factors that cause this gender …
carcinoma (HCC) compared with females. Identifying the factors that cause this gender …
Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis
Androgen/androgen receptor (AR) signaling plays important roles in normal liver function
and in progression of liver diseases. In studies of noncancerous liver diseases, AR knockout …
and in progression of liver diseases. In studies of noncancerous liver diseases, AR knockout …
The androgen receptor as an emerging target in hepatocellular carcinoma
T Kanda, O Yokosuka - Journal of Hepatocellular Carcinoma, 2015 - Taylor & Francis
Hepatocellular carcinoma (HCC) is one of the male-dominant liver diseases with poor
prognosis, although treatments for HCC have been progressing in the past decades …
prognosis, although treatments for HCC have been progressing in the past decades …