TAR RNA Recognition by a Cyclic Peptidomimetic of Tat Protein,
The search for new antiviral drugs that repress HIV viral replication by blocking
transactivation of viral RNA transcription has long been advocated as an approach to novel …
transactivation of viral RNA transcription has long been advocated as an approach to novel …
Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein
A Davidson, K Patora-Komisarska… - Nucleic acids …, 2011 - academic.oup.com
The pharmacological disruption of the interaction between the HIV Tat protein and its
cognate transactivation response RNA (TAR) would generate novel anti-viral drugs with a …
cognate transactivation response RNA (TAR) would generate novel anti-viral drugs with a …
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein
A Davidson, TC Leeper… - Proceedings of the …, 2009 - National Acad Sciences
The interaction of the HIV-1 transactivator protein Tat with its transactivation response (TAR)
RNA is an essential step in viral replication and therefore an attractive target for developing …
RNA is an essential step in viral replication and therefore an attractive target for developing …
Structural mimicry of retroviral tat proteins by constrained β-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements
Z Athanassiou, RLA Dias, K Moehle… - Journal of the …, 2004 - ACS Publications
An approach is described to the design of β-hairpin peptidomimetic ligands for bovine
immunodeficiency virus (BIV) Tat protein, which inhibit binding to its transactivator response …
immunodeficiency virus (BIV) Tat protein, which inhibit binding to its transactivator response …
Structure-Guided Peptidomimetic Design Leads to Nanomolar β-Hairpin Inhibitors of the Tat−TAR Interaction of Bovine Immunodeficiency Virus,
Z Athanassiou, K Patora, RLA Dias, K Moehle… - Biochemistry, 2007 - ACS Publications
The Tat protein of immunodeficiency viruses is the main activator of viral gene expression.
By binding specifically to its cognate site, the transactivator response element (TAR), Tat …
By binding specifically to its cognate site, the transactivator response element (TAR), Tat …
Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells
RNA represents a potential target for new antiviral therapies, which are urgently needed to
address public health threats such as the human immunodeficiency virus (HIV). We showed …
address public health threats such as the human immunodeficiency virus (HIV). We showed …
Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors
RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral
trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to …
trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to …
Inhibitors of protein− RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules
HY Mei, M Cui, A Heldsinger, SM Lemrow, JA Loo… - Biochemistry, 1998 - ACS Publications
TAR RNA represents an attractive target for the intervention of human immunodeficiency
virus type 1 (HIV-1) replication by small molecules. We now describe three small molecule …
virus type 1 (HIV-1) replication by small molecules. We now describe three small molecule …
Targeting RNA with peptidomimetic oligomers in human cells
N Tamilarasu, I Huq, TM Rana - Bioorganic & medicinal chemistry letters, 2001 - Elsevier
Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of
Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop …
Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop …
Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication
S Hwang, N Tamilarasu, K Kibler, H Cao, A Ali… - Journal of Biological …, 2003 - ASBMB
Antiretroviral therapy to treat AIDS uses molecules that target the reverse transcriptase and
protease enzymes of human immunodeficiency virus, type 1 (HIV-1). A major problem …
protease enzymes of human immunodeficiency virus, type 1 (HIV-1). A major problem …