Background Vascular congestion of the renal medulla—trapped red blood cells in the
medullary microvasculature—is a hallmark finding at autopsy in patients with ischemic acute …

The kidneys receive approximately 20% of cardiac output and have a low fractional oxygen
extraction. Quite paradoxically, however, the kidneys are highly susceptible to ischemic …

Acute kidney injury (AKI) represents a sudden reduction in renal function and is a major
clinical problem with a high mortality rate. Despite decades of research, there are currently …

Mortality in acute kidney injury (AKI) patients remains very high, although very important
advances in understanding the pathophysiology and in diagnosis and supportive care have …

Ischemic acute kidney injury is common, deadly, and accelerates the progression of chronic
kidney disease, yet has no specific therapy. After ischemia, reperfusion is patchy with early …

In this study, we compared the traditional murine model with renal pedicle clamp with
models that clamped the renal artery or vein alone as well as to a whole body ischemia …

The renal microcirculation plays a major role in the delivery of blood and oxygen to the
kidney. In sepsis, alterations in renal microvascular perfusion, in conjunction with increased …

Recent evidence suggests that a greater density of pericytes in renal cadaveric allografts is
associated with better recovery following transplant. The physiological mechanism (s) …

Key points Transient reduction in renal blood flow results in inflammation and is a primary
cause of acute kidney injury, thereby representing a major clinical problem. It is not known …

To study the effect of renal ischemia on the circulation in the inner medulla, blood flow in
descending and ascending vasa recta was determined by fluorescence videomicroscopy in …