The aim of the current study was to determine whether renal medullary oxygenation is
independent of the level of cortical blood flow by testing responses to stimuli that selectively …

The mortality rate for septic patients with acute renal failure is extremely high. Since sepsis is
often caused by lipopolysaccharide (LPS), a model of LPS challenge was used to study the …

Alterations in renal microperfusion play an important role in the development of acute kidney
injury with long-term consequences. Here we used contrast-enhanced ultrasonography as a …

Glycine preserves tubular cell integrity under hypoxic and toxic conditions in vitro. It also
ameliorates cisplatin nephrotoxicity in vivo. We studied the effect of glycine on tubular …

Microvascular endothelial injury and dysfunction during ischemic acute renal failure. The
pathophysiology of ischemic acute renal failure (ARF) appears to involve a complex …

Background The etiology of renal dysfunction in sepsis is currently attributed to altered
perfusion, microcirculatory abnormalities and cellular alterations. To clarify these …

The pathophysiology of ischemic renal injury is complex. There is clearly an important
vascular component to the injury, not only at the level of total renal perfusion but also at the …

More than 70% of acute renal failure in man is of circulatory nature and results from hypoxic
injury to the kidney. Since intrarenal hemodynamic and metabolic events cannot be …

Objective Extracorporeal circulation is routinely used in thoracoabdominal aortic aneurysm
repair to preserve blood perfusion. Despite this protective measure, acute and chronic …

Background/Aims: To date, there is no imaging technique to assess tubular function in vivo.
Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue …