It is hypothesized that rarefaction of peritubular capillaries represents a critical event,
following ischemic injury, that permanently alters renal function and predisposes patients to …

Acute renal failure (ARF) is a frequent and serious complication of endotoxemia caused by
lipopolysaccharide (LPS) and contributes significantly to mortality. The present studies were …

It is not known whether a kidney with chronic structural and functional changes is more
vulnerable to an acute renal insult, and whether its regeneration capacity after injury is …

Methods Ischemic ARF was induced by renal clamping for 22 min, while the control mice
underwent sham surgery (no clamping). The serum creatinine and blood urea nitrogen …

Acute kidney injury following traumatic brain injury is associated with poor outcome. We
investigated in vitro the effects of plasma of brain injured patients with acute tubular kidney …

Decreased renal blood flow following an ischemic insult contributes to a reduction in
glomerular filtration. However, little is known about the underlying cellular or subcellular …

BACKGROUND: Gradually increased blood flow to the ischemic rat kidney was studied to
assess the ability to diminish ischemia-reperfusion injury. METHODS: The left renal artery …

Urine output is widely used as a criterion for the diagnosis of AKI. Although several potential
mechanisms of septic AKI have been identified, regulation of urine flow after glomerular …

Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …

Background Complement activation plays an important role in the pathogenesis of renal
ischemia-reperfusion (IR) injury (IRI), but whether this involves damage to the …