Background and Aims Mutations in DNA mismatch repair (MMR) genes are causative in
Lynch syndrome and a significant proportion of sporadic colorectal cancers (CRCs). MMR …

Lynch syndrome is the most common cause of hereditary colorectal cancer and is secondary
to germline alterations in one of four DNA mismatch repair (MMR) genes. Here we aimed to …

The gut microbiota strongly impacts the development of sporadic colorectal cancer (CRC),
but it is largely unknown how the microbiota affects the pathogenesis of mismatch-repair …

Colorectal cancer is a multifactorial disease involving inherited DNA mutations,
environmental factors, gut inflammation and intestinal microbiota. Certain germline …

Colorectal cancer (CRC) genome is unstable and different types of instabilities, such as
chromosomal instability (CIN) and microsatellite instability (MSI) are thought to reflect distinct …

Colorectal cancer (CRC) remains one of the most prevalent cancers worldwide. In sporadic
CRC, mutations frequently occur in the DNA mismatch repair (MMR) pathway. In addition …

Background & Aims Lynch syndrome, a nonpolyposis form of hereditary colorectal cancer, is
caused by inherited defects in DNA mismatch repair (MMR) genes. Most patients carry a …

Sporadic human mismatch repair (MMR)–deficient colorectal cancers account for∼ 12.5%
of all cases of colorectal cancer. MMR-deficient colorectal cancers are classically …

Objective Macrophages are among the most abundant cells in the colon tumour
microenvironment, and there is a close relationship among monocytes, macrophages and …

The etiology of colorectal cancer (CRC) has been linked to deficiencies in mismatch repair
and adenomatous polyposis coli (APC) proteins, diet, inflammatory processes, and gut …