Autoimmunity results from a break in self-tolerance involving humoral and/or cell-mediated
immune mechanisms. One pathological consequence of a failure in central and/or …

BAFF (B lymphocyte activating factor of the tumour necrosis factor family) is a vital
homeostatic cytokine for B cells that helps regulate both innate and adaptive immune …

The prevailing treatment strategies for autoimmune disorders employ global
immunosuppressants that have harmful side effects with long-term use. A new vision for …

BAFF [B‐cell activating factor belonging to the tumor necrosis factor (TNF) family] is a ligand
that is required for peripheral B‐cell survival and homeostasis. In addition to mediating B …

BAFF and APRIL are TNF-like cytokines that support survival and differentiation of B cells.
The early appreciation that overexpression of BAFF leads to B cell expansion and a lupus …

In an effort to develop more effective treatments for inflammatory diseases, immunologists
have targeted numerous molecular pathways, but with limited success. Notable exceptions …

B cells require signals from multiple sources for their development from precursor cells, and
differentiation into effector cells. BAFF has been identified as a critical regulator of B cell …

The TNF family member BAFF is a fundamental survival factor for B cells. BAFF binds to
three receptors, only one of which, BAFF-R, does not cross-react with the BAFF-related …

The TNF-family cytokine BAFF (BLyS) promotes B lymphocyte survival and is overexpressed
in individuals with systemic lupus erythematosus and Sjögren's Syndrome. BAFF can rescue …

BAFF (BLyS) and APRIL are TNF-like cytokines that support survival and differentiation of B
cells. Recent studies have discovered a role for BAFF in augmenting both innate and …