All cells exist within the context of a three-dimensional microenvironment in which they are
exposed to mechanical and physical cues. These cues can be disrupted through …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Mechanical stresses are ever present in the cellular environment, whether through external
forces that are applied to tissues or endogenous forces that are generated within the active …

All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …

Cells actively sense and process mechanical information that is provided by the extracellular
environment to make decisions about growth, motility and differentiation. It is important to …

Cells sense their physical surroundings through mechanotransduction—that is, by
translating mechanical forces and deformations into biochemical signals such as changes in …

Cells are exposed to a variety of mechanical cues, including forces from their local
environment and physical properties of the tissue. These mechanical cues regulate a vast …

Cellular responses to mechanical forces are crucial in embryonic development and adult
physiology, and are involved in numerous diseases, including atherosclerosis …

It is increasingly clear that mechanotransduction pathways play important roles in regulating
fundamental cellular functions. Of the basic mechanical functions, the determination of …

The shapes of eukaryotic cells and ultimately the organisms that they form are defined by
cycles of mechanosensing, mechanotransduction and mechanoresponse. Local sensing of …