[HTML][HTML] Perspective insights into disease progression, diagnostics, and therapeutic approaches in Alzheimer's disease: a judicious update

AT Jan, M Azam, S Rahman, AMS Almigeiti… - Frontiers in aging …, 2017 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive
accumulation of β-amyloid fibrils and abnormal tau proteins in and outside of neurons …

[HTML][HTML] Clinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer's disease

I Mumtaz, MO Ayaz, MS Khan, U Manzoor… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder that causes progressive loss of
cognitive functions like thinking, memory, reasoning, behavioral abilities, and social skills …

Multifaceted Alzheimer's disease: Building a roadmap for advancement of novel therapies

D Kaur, T Behl, A Sehgal, S Singh, N Sharma… - Neurochemical …, 2021 - Springer
Alzheimer's disease (AD) is one of the most prevailing neurodegenerative disorders of
elderly humans associated with cognitive damage. Biochemical, epigenetic, and …

Clinical research on Alzheimer's disease: progress and perspectives

BL Sun, WW Li, C Zhu, WS Jin, F Zeng, YH Liu… - Neuroscience …, 2018 - Springer
Abstract Alzheimer's disease (AD), the most common type of dementia, is becoming a major
challenge for global health and social care. However, the current understanding of AD …

[HTML][HTML] Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …

Recent update on the Alzheimer's disease progression, diagnosis and treatment approaches

A Malaiya, M Singhai, M Singh, SK Prajapati… - Current Drug …, 2022 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disorder,
manifested by the loss of memory and cognitive abilities, behavioral disturbance and …

[HTML][HTML] An insight into cellular and molecular mechanisms underlying the pathogenesis of neurodegeneration in Alzheimer's disease

Y Ratan, A Rajput, S Maleysm, A Pareek, V Jain… - Biomedicines, 2023 - mdpi.com
Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

[HTML][HTML] Developing effective therapeutics for Alzheimer's disease—emerging mechanisms and actions in translational medicine

C Zhang - Discovery medicine, 2017 - discoverymedicine.com
Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder.
Presently there are no effective disease-modifying therapies. Although mutations in specific …

[HTML][HTML] Alzheimer's disease–the journey of a healthy brain into organ failure

TE Golde - Molecular Neurodegeneration, 2022 - Springer
As the most common dementia, Alzheimer's disease (AD) exacts an immense personal,
societal, and economic toll. AD was first described at the neuropathological level in the early …

[HTML][HTML] Development of Alzheimer's disease biomarkers: From CSF-to blood-based biomarkers

S Mankhong, S Kim, S Lee, HB Kwak, DH Park, KL Joa… - Biomedicines, 2022 - mdpi.com
In the 115 years since the discovery of Alzheimer's disease (AD), our knowledge, diagnosis,
and therapeutics have significantly improved. Biomarkers are the primary tools for clinical …