[PDF][PDF] The Role of GATA-1 in Megakaryocyte Function and Platelet Production During HIV Infection: A Review

EI Obeagu, GU Obeagu - Elite Journal of Scientific Research and …, 2024 - researchgate.net
GATA-1, a key transcription factor, plays a crucial role in regulating megakaryocyte function
and platelet production. In the context of HIV infection, dysregulation of GATA-1 signaling …

[PDF][PDF] Role of GATA-1 in Megakaryopoiesis and Thrombopoiesis During HIV Infection: Molecular Insights and Therapeutic Implications

EI Obeagu, GU Obeagu - Elite Journal of Nursing and Health …, 2024 - researchgate.net
Thrombocytopenia is a common hematological complication in individuals living with
Human Immunodeficiency Virus (HIV) infection, often resulting from dysregulated …

[PDF][PDF] GATA-1 and Hematopoietic Stem Cell Maintenance in HIV: Mechanisms and Implications

EI Obeagu, GU Obeagu - Elite Journal of Health Science, 2024 - researchgate.net
Hematopoietic stem cells (HSCs) are pivotal for maintaining blood cell production and
immune function, and their dysregulation is implicated in hematological abnormalities …

[PDF][PDF] GATA-1 Regulation of Erythroid Progenitor Cell Differentiation in HIV/AIDS: Molecular Insights and Therapeutic Implications

EI Obeagu, GU Obeagu - Elite Journal of Haematology, 2024; 2 (4 …, 2024 - researchgate.net
Anemia is a prevalent complication of HIV/AIDS, often stemming from dysregulated
erythropoiesis characterized by impaired differentiation of erythroid progenitor cells. GATA …

[PDF][PDF] Exploration of Intricate Relationship between GATA-1 and Anemia in HIV

EI Obeagu, GU Obeagu - Elite Journal of Haematology, 2024; 2 (4 …, 2024 - researchgate.net
Anemia is a prevalent complication in individuals living with HIV/AIDS, contributing
significantly to morbidity and mortality. Despite advancements in treatment, anemia remains …

[PDF][PDF] GATA-1 and Bone Marrow Failure Syndromes in the Context of HIV Infection: A Review of Molecular Mechanisms and Therapeutic Implications

EI Obeagu, GU Obeagu - Elite Journal of Laboratory Medicine, 2024 - researchgate.net
Bone marrow failure syndromes, characterized by impaired hematopoiesis leading to
cytopenias, represent significant complications in individuals living with HIV infection. GATA …

[PDF][PDF] Understanding the Role of GATA-1 in T-Cell Development in the Context of HIV Infection

OGU ObeaguEI - Elite Journal of HIV, 2024 - researchgate.net
T-cell dysfunction is a hallmark feature of HIV infection, contributing to disease progression
and susceptibility to opportunistic infections. GATA-1, a key transcription factor traditionally …

[PDF][PDF] GATA-1 and HIV-Associated Myelodysplastic Syndromes: Pathogenesis and Treatment Strategies

EI Obeagu, GU Obeagu - Elite Journal of Medicine, 2024 - researchgate.net
Myelodysplastic syndromes (MDS) pose a significant clinical challenge in individuals with
Human Immunodeficiency Virus (HIV) infection, characterized by dysregulated …

[PDF][PDF] GATA-1 and Inflammatory Signaling Pathways in HIV-Related Hematological Disorders: Mechanisms and Therapeutic Implications

EI Obeagu, GU Obeagu - Elite Journal of Health Science, 2024 - researchgate.net
Hematological disorders are common complications of HIV infection, characterized by
immune dysregulation, chronic inflammation, and aberrant hematopoiesis. GATA-1, a critical …

[PDF][PDF] GATA-1 and Coagulation Cascade Regulation in HIV-Associated Hematological Complications: Mechanisms and Therapeutic Implications

EI Obeagu, GU Obeagu - Elite Journal of Health Science, 2024 - researchgate.net
Hematological complications, including thrombosis and bleeding disorders, are significant
contributors to morbidity and mortality in individuals living with Human Immunodeficiency …