LATENT HERPES VIRUS REACTIVATION IN SPACE AND THE EFFECTS OF SIMULATED MICROGRAVITY ON CMV INFECTION

B Rooney - 2020 - uh-ir.tdl.org
Cytomegalovirus (CMV) is a common beta-herpes-virus that is oftentimes shed in the body
fluids of astronauts during short space shuttle (10-16 days) and longer International Space …

Immune system in space: general introduction and observations on stress-sensitive regulations

B Crucian, A Choukér - Stress Challenges and Immunity in Space: From …, 2020 - Springer
Numerous studies have indicated that spaceflight results in dysregulation of the human
immune system. This phenomenon has been well documented following flight, where …

Maintaining the Body's Immune System: Incidence of Latent Virus Shedding During Space Flight

D Pierson, J Bloomberg, A Lee - 2002 - ntrs.nasa.gov
Your body protects you from illness with its own security system-the immune system. This
system keeps illness at bay not only by mounting a defense against foreign organisms, but …

Latent Herpes Viruses Reactivation In Astronauts

SK Mehta, DL Pierson - 2008 - ntrs.nasa.gov
Space flight has many adverse effects on human physiology. Changes in multiple systems,
including the cardiovascular, musculoskeletal, neurovestibular, endocrine, and immune …

Latent virus reactivation in astronauts on the international space station

SK Mehta, ML Laudenslager, RP Stowe, BE Crucian… - npj …, 2017 - nature.com
Reactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5 female)
before, during, and after long-duration (up to 180 days) spaceflight onboard the international …

Longitudinal analysis of viral shedding in astronauts before, during, and after a mission to the International Space Station

FJSMO Moreira - 2022 - repositorio.ul.pt
Herpesviruses were measured in 23 astronauts with the objective of understanding their
reactivation pattern during a long-duration space mission. The measurements consisted of …

Kaposi's sarcoma-associated herpesvirus is cell-intrinsically controlled in latency in microgravity

T Honda, R Nakayama, Y Kawahara, L Yuge, K Ueda - Virus research, 2020 - Elsevier
In the next several decades, humans will explore deep space, including Mars. During long-
term space flight, astronauts will be exposed to various physical stressors. Among these …

Stress, Spaceflight, and Latent Herpes Virus Reactivation

RP Stowe, DL Pierson, SK Mehta - Stress Challenges and Immunity in …, 2020 - Springer
The effect of stress on immune responses associated with manned space missions is
unknown, but concern of diminished immunity on long missions is problematic. Decreased …

Immune System Dysregulation and Herpesvirus Reactivation Persist during Long-Duration Spaceflight

BE Crucian, RP Stowe, S Mehta, P Uchakin… - 18th IAA Humans in …, 2010 - ntrs.nasa.gov
Background: Immunity, latent herpesvirus reactivation, physiological stress and circadian
rhythms were assessed during six month spaceflight onboard ISS. Blood and saliva samples …

Reactivation of latent viruses is associated with increased plasma cytokines in astronauts

SK Mehta, BE Crucian, RP Stowe, RJ Simpson, CM Ott… - Cytokine, 2013 - Elsevier
Success of long duration space missions will depend upon robust immunity. Decreased
immunity has been observed in astronauts during short duration missions, as evident by the …