Microvascular growth and remodeling processes are essential to tissue maintenance and
repair. While several biochemical regulators have been elucidated, the effects of dynamic …

The microvasculature is an extremely adaptable structure that is capable of architectural and
functional adjustments in response to multiple biochemical and mechanical stimuli …

Microvascular network remodelling is a common denominator for multiple pathologies and
involves both angiogenesis, defined as the sprouting of new capillaries, and network …

Neovascularization is a critical early step toward successful tissue regeneration during
wound healing. While vasculature has long been recognized as highly mechanosensitive (to …

Abstract This Special Topic Issue is concerned with the mechanisms that determine the
structure of microvascular networks. The vast number of vessels and the highly plastic …

The microvasculature is a dynamic cellular system necessary for tissue health and function.
Therapeutic strategies that target the microvasculature are expanding and evolving …

During angiogenesis, sprouting microvessels interact with the extracellular matrix (ECM) by
degrading and reorganizing the matrix, applying traction forces, and producing deformation …

Microvascular remodeling is a complex process that includes many cell types and molecular
signals. Despite a continued growth in the understanding of signaling pathways involved in …

Combined with in vitro and in vivo experiments, mathematical and computational modeling
are key to unraveling how mechanical and chemical signaling by endothelial cells …

Proper tissue repair or de novo regeneration requires formation of a patent extensive three-
dimensional vascular network that meets the specific oxygen demands of the tissue …