Antibiofilm activity of host defence peptides: Complexity provides opportunities

REW Hancock, MA Alford, EF Haney - Nature Reviews Microbiology, 2021 - nature.com
Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …

[HTML][HTML] Synthetic antibiofilm peptides

C De La Fuente-Núñez, MH Cardoso… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Bacteria predominantly exist as multicellular aggregates known as biofilms that are
associated with at least two thirds of all infections and exhibit increased adaptive resistance …

Host defense (antimicrobial) peptides

E Sun, CR Belanger, EF Haney… - Peptide applications in …, 2018 - Elsevier
Small cationic, amphipathic peptides with critical roles in host defenses often exhibit
overlapping but distinct immunomodulatory activity, direct antimicrobial activity towards …

[HTML][HTML] Strategies in translating the therapeutic potentials of host defense peptides

DSJ Ting, RW Beuerman, HS Dua… - Frontiers in …, 2020 - frontiersin.org
The golden era of antibiotics, heralded by the discovery of penicillin, has long been
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …

Antimicrobial host defence peptides: immunomodulatory functions and translational prospects

AM van der Does, PS Hiemstra… - … Peptides: Basics for …, 2019 - Springer
Cationic host defence peptides (CHDPs), also known as antimicrobial peptides, exhibit a
wide range of activities contributing to immune responses and resolution of infections …

Antibiofilm peptides: overcoming biofilm-related treatment failure

M Dostert, MJ Trimble, REW Hancock - RSC advances, 2021 - pubs.rsc.org
Health leaders and scientists worldwide consider antibiotic resistance among the world's
most dangerous pathogens as one of the biggest threats to global health. Antibiotic …

Antimicrobial host defence peptides: functions and clinical potential

N Mookherjee, MA Anderson, HP Haagsman… - Nature reviews Drug …, 2020 - nature.com
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …

Multifunctional cationic host defence peptides and their clinical applications

ATY Yeung, SL Gellatly, REW Hancock - Cellular and Molecular Life …, 2011 - Springer
With the rapid rise in the emergence of bacterial strains resistant to multiple classes of
antimicrobial agents, there is an urgent need to develop novel antimicrobial therapies to …

Antimicrobial and antibiofilm peptides

A Di Somma, A Moretta, C Canè, A Cirillo, A Duilio - Biomolecules, 2020 - mdpi.com
The increasing onset of multidrug-resistant bacteria has propelled microbiology research
towards antimicrobial peptides as new possible antibiotics from natural sources …

Perspectives for clinical use of engineered human host defense antimicrobial peptides

ME Pachón-Ibáñez, Y Smani, J Pachon… - FEMS microbiology …, 2017 - academic.oup.com
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of
death worldwide. The emergence of drug-resistance mechanisms, especially among …