Multifunctional host defense peptides: antimicrobial peptides, the small yet big players in innate and adaptive immunity

C Auvynet, Y Rosenstein - The FEBS journal, 2009 - Wiley Online Library
The term 'antimicrobial peptides' refers to a large number of peptides first characterized on
the basis of their antibiotic and antifungal activities. In addition to their role as endogenous …

[HTML][HTML] Multifunctional antimicrobial peptides: therapeutic targets in several human diseases

M Zaiou - Journal of Molecular Medicine, 2007 - Springer
Antimicrobial peptides have emerged as promising agents against antibiotic-resistant
pathogens. They represent essential components of the innate immunity and permit humans …

Antimicrobial peptides

M Malmsten - Upsala journal of medical sciences, 2014 - Taylor & Francis
With increasing antibiotics resistance, there is an urgent need for novel infection
therapeutics. Since antimicrobial peptides provide opportunities for this, identification and …

Host antimicrobial defence peptides in human disease

B Agerberth, GH Guðmundsson - Antimicrobial peptides and human …, 2006 - Springer
Antimicrobial peptides or host defence peptides are endogenous peptide antibiotics, which
have been confirmed as an essential part of the immune system. Apart from direct killing of …

An overview of antimicrobial peptides and the latest advances in their development

JM Sierra, E Fusté, F Rabanal, T Vinuesa… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: The recent dramatic increase in the incidence of antimicrobial resistance has
been recognized by organizations such as the United Nations and World Health …

[HTML][HTML] Multitalented synthetic antimicrobial peptides and their antibacterial, antifungal and antiviral mechanisms

T Vanzolini, M Bruschi, AC Rinaldi, M Magnani… - International Journal of …, 2022 - mdpi.com
Despite the great strides in healthcare during the last century, some challenges still
remained unanswered. The development of multi-drug resistant bacteria, the alarming …

Cationic antimicrobial peptides and their multifunctional role in the immune system

MG Scott, REW Hancock - Critical Reviews™ in Immunology, 2000 - dl.begellhouse.com
Many species of life contain cationic antimicrobial peptides as components of their immune
systems. The antimicrobial activity of these peptides has been studied extensively, and …

Antimicrobial peptides: an introduction

EF Haney, SC Mansour, REW Hancock - Antimicrobial peptides: methods …, 2017 - Springer
The “golden era” of antibiotic discovery has long passed, but the need for new antibiotics
has never been greater due to the emerging threat of antibiotic resistance. This urgency to …

Peptide IDR‐1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic‐resistant bacterial infections

SC Mansour, C de la Fuente‐Núñez… - Journal of Peptide …, 2015 - Wiley Online Library
Host defense (antimicrobial) peptides, produced by all complex organisms, typically contain
an abundance of positively charged and hydrophobic amino acid residues. A small synthetic …

Antimicrobial peptides–promising alternatives to conventional antibiotics

SA Baltzer, MH Brown - Microbial Physiology, 2011 - karger.com
Antimicrobial peptides (APs) have been described as evolutionary ancient weapons.
Produced by a wide variety of organisms as part of a non-specific immune response, these …