Previous report indicated that nicorandil potentiated morphine antinociception and
attenuated hepatic injury in liver fibrotic rats. Herein, the underlying mechanisms of …

Aims Chronic liver disease (CLD) is a serious medical condition affecting patients globally
and pain management poses a unique challenge. ATP-sensitive potassium channels (K …

Aims: Liver cirrhosis is the irreversible end result of‎ fibrous scarring and associated with
prominent morbidity and mortality. We aimed to investigate the involvement of nitrergic and …

Aims It is well-established that thrombospondin-1 (THBS-1), vascular endothelial growth
factor-A (VEGF-A), nuclear factor-erythroid 2-related factor 2 (Nrf-2), Kelch-like ECH …

Liver fibrosis is one of the most serious conditions affecting patients worldwide. In the
present study, the role of nitric oxide and KATP channel was investigated for the first time in …

Aim: The aim of this study was to investigate the hypothesis that the opioid system is
involved in the development of hepatic fibrosis. Methods: The effect of naltrexone (an opioid …

The opioid system is widely known to modulate the brain reward system and thus affect the
behavior of humans and other animals, including feeding. We hypothesized that the …

Hepatic fibrosis is characterized by excess type I collagen deposition and exacerbated
inflammatory response. Naltrexone, an opioid receptor antagonist used for treating alcohol …

The purpose of this study was to investigate the role of the L-arginine/nitric oxide (NO)/cGMP
pathway in p-benzoquinone-induced writhing model in mouse. L-arginine, a NO precursor …

Recent studies suggest endogenous opioids and nitric oxide (NO) are involved in the
pathophysiology of hepatic encephalopathy (HE). In this study, the interaction between the …