Versatile Nanoparticulate Systems as a Prosperous Platform for Targeted Nose–Brain Drug Delivery

E Taha, A Shetta, SA Nour, MJ Naguib… - Molecular …, 2024 - ACS Publications
The intranasal route has proven to be a reliable and promising route for delivering
therapeutics to the central nervous system (CNS), averting the blood–brain barrier (BBB) …

New Insights into Nanoparticulate Carriers for Direct Nose‐to‐Brain Drug Delivery

CV Pardeshi, M Handa, R Shukla - Nanoengineering of …, 2022 - Wiley Online Library
Disorders related to central nervous system (CNS) like schizophrenia, Parkinson's disease,
and Alzheimer's disease need transport of the medication to the specific site in the brain for …

Intranasal nanoparticulate systems as alternative route of drug delivery

A Alshweiat, R Ambrus, II Csóka - Current medicinal chemistry, 2019 - ingentaconnect.com
There is always a need for alternative and efficient methods of drug delivery. The nasal
cavity can be considered as a non-invasive and efficient route of administration. It has been …

Potential of nanoparticulate drug delivery systems by intranasal administration

J Ali, M Ali, S Baboota, J Kaur Sahni… - Current …, 2010 - ingentaconnect.com
Due to number of problems related with oral, parenteral, rectal and other routes of drug
administration, the interest of pharmaceutical scientists has increased towards exploring the …

Brain targeting of drugs via intranasal route in conjunction with nanoparticle-based systems: an updated review

A Furquan, A Hafeez, MA Rahman - Journal of Nanoparticle Research, 2023 - Springer
The prevalence of neurological illnesses, such as epilepsy, Alzheimer's disease,
Parkinson's disease, glioblastoma, and multiple sclerosis, is rising globally; there is still a …

Nanoparticles for direct nose-to-brain drug delivery: implications of targeting approaches

RO Sonawane, Y Bachhav, AR Tekade… - Direct Nose-to-Brain …, 2021 - Elsevier
The use of nanocarriers for pharmaceutical and clinical applications is a well-established
archetype since long time. These nanoparticulate carriers are expected to stay in blood for …

Intranasal nanoparticulate delivery systems for neurodegenerative disorders: a review

SR Babu, HH Shekara, AK Sahoo… - Therapeutic …, 2023 - Future Science
Neurodegenerative diseases are a significant cause of mortality worldwide, and the blood–
brain barrier (BBB) poses a significant challenge for drug delivery. An intranasal route is a …

Nanoneurotherapeutics approach intended for direct nose to brain delivery

S Md, G Mustafa, S Baboota, J Ali - Drug development and …, 2015 - Taylor & Francis
Context: Brain disorders remain the world's leading cause of disability, and account for more
hospitalizations and prolonged care than almost all other diseases combined. The majority …

[HTML][HTML] Intranasal delivery of nanoformulations: a potential way of treatment for neurological disorders

SU Islam, A Shehzad, MB Ahmed, YS Lee - Molecules, 2020 - mdpi.com
Although the global prevalence of neurological disorders such as Parkinson's disease,
Alzheimer's disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing …

Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway

Y Chen, C Zhang, Y Huang, Y Ma, Q Song… - Advanced Drug Delivery …, 2024 - Elsevier
We overviewed the anatomy and physiology of the nose-to-brain pathway, along with the
mechanisms involved. We then summarized the interaction process between nanoparticles …